Featured Research

from universities, journals, and other organizations

Gene Mutations Found That Lead To Prostate Cancer In Mice

Date:
January 31, 2001
Source:
Memorial Sloan-Kettering Cancer
Summary:
Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) report in the February issue of Nature Genetics that inactivation of just one copy of a gene called PTEN and both copies of a gene called p27 leads to prostate cancer in mice 100 percent of the time. Mutations in the PTEN gene are frequently found in human prostate cancer. And, for the first time, scientists now have a mouse model for prostate cancer in which the tumors have the same features as prostate tumors in humans.

NEW YORK, January 30, 2001 -- Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) report in the February issue of Nature Genetics that inactivation of just one copy of a gene called PTEN and both copies of a gene called p27 leads to prostate cancer in mice 100 percent of the time. Mutations in the PTEN gene are frequently found in human prostate cancer. And, for the first time, scientists now have a mouse model for prostate cancer in which the tumors have the same features as prostate tumors in humans. According to the study's lead author, Pier Paolo Pandolfi, M.D., Ph.D., Head of the Molecular and Developmental Biology Laboratory at Memorial Sloan-Kettering, having this model will lead to better methods for testing potential new drugs to fight the disease.

These mutations provide insight into genetic variations that may lead to more severe forms of prostate cancer in humans. MSKCC researchers had previously found that loss of the p27 protein in men led to a higher rate of recurrence for prostate cancer and a poorer long-term survival. The new finding may allow doctors to eventually refine their diagnosis and treatment of tumor types in men.

However, further research is needed to determine if these gene mutations affect humans in the same way they affect mice. In addition, testing for these gene mutations is not readily available at this time. Prostate cancer experts stress the importance of clinical trials in future research.


Story Source:

The above story is based on materials provided by Memorial Sloan-Kettering Cancer. Note: Materials may be edited for content and length.


Cite This Page:

Memorial Sloan-Kettering Cancer. "Gene Mutations Found That Lead To Prostate Cancer In Mice." ScienceDaily. ScienceDaily, 31 January 2001. <www.sciencedaily.com/releases/2001/01/010131074040.htm>.
Memorial Sloan-Kettering Cancer. (2001, January 31). Gene Mutations Found That Lead To Prostate Cancer In Mice. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2001/01/010131074040.htm
Memorial Sloan-Kettering Cancer. "Gene Mutations Found That Lead To Prostate Cancer In Mice." ScienceDaily. www.sciencedaily.com/releases/2001/01/010131074040.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins