Featured Research

from universities, journals, and other organizations

University Of Kentucky Researchers Find Critical Link For Estrogen's Neuroprotective Effects

Date:
February 13, 2001
Source:
University Of Kentucky Medical Center
Summary:
University of Kentucky College of Medicine researchers have determined that one specific estrogen receptor, called ERa, is a critical link in mediating the protective effects of estradiol in brain injury.

University of Kentucky College of Medicine researchers have determined that one specific estrogen receptor, called ERa, is a critical link in mediating the protective effects of estradiol in brain injury. The study was led by Phyllis Wise, Ph.D., professor and chair, and Dena Dubal, graduate student in the M.D./Ph.D. program, of the Department of Physiology, UK College of Medicine, and appears in the Feb. 6 online issue and the Feb. 13 issue of the Proceedings of the National Academy of Sciences.

Previous research by Wise’s team has demonstrated that estradiol, a type of estrogen, protects against brain injury (including injury from stroke), neurodegeneration and cognitive decline. The UK College of Medicine research team examined whether estrogen receptors are critical for estrogen’s neuroprotective effects. The team focused on two estrogen receptor types, ERa and ERb. Using animal models in which one of the receptor types had been deleted, they demonstrated that when ERa is absent, estradiol no longer has protective effects in any area of the brain. But when ERb is absent, estradiol still provides effective neuroprotection.

“We have demonstrated that future research and development for therapies that capitalize on estradiol’s neuroprotective effects should focus on ERa,” Wise said. “These results have tremendous implications for developing therapeutic agents for treating brain injuries.”


Story Source:

The above story is based on materials provided by University Of Kentucky Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Kentucky Medical Center. "University Of Kentucky Researchers Find Critical Link For Estrogen's Neuroprotective Effects." ScienceDaily. ScienceDaily, 13 February 2001. <www.sciencedaily.com/releases/2001/02/010213071752.htm>.
University Of Kentucky Medical Center. (2001, February 13). University Of Kentucky Researchers Find Critical Link For Estrogen's Neuroprotective Effects. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2001/02/010213071752.htm
University Of Kentucky Medical Center. "University Of Kentucky Researchers Find Critical Link For Estrogen's Neuroprotective Effects." ScienceDaily. www.sciencedaily.com/releases/2001/02/010213071752.htm (accessed July 28, 2014).

Share This




More Mind & Brain News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com
University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins