Featured Research

from universities, journals, and other organizations

Scientists Activate Bone Cell Rescue Pathway

Date:
March 12, 2001
Source:
University Of Arkansas For Medical Sciences
Summary:
By manipulating how sex steroids are processed in bone-building cells called osteoblasts, a research team at the University of Arkansas for Medical Sciences (UAMS) in Little Rock, Arkansas, led by Stavros C. Manolagas, M.D., Ph.D., has shown it may be possible to increase the survival of these cells. "This research points the way to avoiding many of the complications associated with current estrogen hormone replacement therapy," Dr. Manolagas said.

(Little Rock, AR) Twenty-eight million Americans have reason for new hope in dealing with osteoporosis - a devastating bone-wasting process that puts half of older women and one in eight men over 50 at greater risk of hip and other debilitating bone fractures.

By manipulating how sex steroids are processed in bone-building cells called osteoblasts, a research team at the University of Arkansas for Medical Sciences (UAMS) in Little Rock, Arkansas, led by Stavros C. Manolagas, M.D., Ph.D., has shown it may be possible to increase the survival of these cells. "This research points the way to avoiding many of the complications associated with current estrogen hormone replacement therapy," Dr. Manolagas said.

The finding, published in the March 9, 2001 issue of the scientific journal, Cell, could have important implications for the development of new drugs to prevent or treat osteoporosis in both women and men.

In cell culture experiments, the UAMS research team successfully used synthetic molecules that mimic some good yet avoid the bad effects of estrogen, a sex hormone present in women and men. They selectively activated the anti-apoptosis, or "cell rescue" pathway of estrogen and androgen receptors in mouse bone cells. By activating only this pathway, the scientists were able to promote the longevity of osteoblasts, the cells that lay down new bone, without sparking detrimental sex steroid activities within the cell. Preserving osteoblasts could help prevent osteoporosis, a bone-wasting disease, which is a major health risk to persons over age 50.

"Our work, for the first time, delineates the way sex steroids might protect bone-forming and bone-maintaining cells from cell death in both women and men. This presents an opportunity for unisex application of our work," Manolagas said. He believes the research is the foundation for developing new and improved treatments for osteoporosis based on only the "good" properties of estrogen.

Manolagas is the Director of the Division of Endocrinology and Metabolic Bone Diseases and a Professor of Medicine at the UAMS College of Medicine. He serves as a faculty physician and researcher at UAMS Medical Center and the Central Arkansas Veterans Healthcare System.

Jill Carrrington, Ph.D., director of the musculoskeletal biology program at National Institute on Aging, commented, "With further work to understand this mechanism, it may be possible to design new treatments for osteoporosis." The National Institute on Aging (NIA) and the National Institute on Arthritis and Musculoskeletal and Skin Diseases (NIAMS), two components of the National Institutes of Health (NIH) in Bethesda, Maryland, supported the research.

The research team includes: S. Kousteni, T. Bellido, D.L. Bodenner, K. Han., J.A. Katzenellenbogen, B.S., Katzenllenbogen, P.K. Roberson, R.S. Weinstein, R.L. Jilka, and S.C. Manolagas. The article is entitled, "Non-Genotropic, Sex Non-Specific Signaling Through The Classical Estrogen or Androgen Receptors: Dissociation From Transcriptional Activity."

In the United States today, 10 million individuals already have osteoporosis and 18 million more have low bone mass, placing them at increased risk for this disease. Osteoporosis is responsible for more than 1.5 million fractures annually, including 300,000 hip fractures, approximately 700,000 vertebral (spinal) fractures, 250,000 wrist fractures, and more than 300,000 fractures at other sites. In addition to hormone replacement therapy, exercise and adequate intake of calcium and vitamin D can help preserve bone mass and prevent or slow osteoporosis in older women and men.

The National Institute on Aging is a component of the National Institutes of Health, U.S. Department of Health and Human Services. The NIA and the NIAMS, are two of 26 institutes and centers that compose the NIH. The NIA leads the federal effort supporting and conducting research on aging and age-related diseases and special needs of older people. NIAMS leads the Federal effort on research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases.


Story Source:

The above story is based on materials provided by University Of Arkansas For Medical Sciences. Note: Materials may be edited for content and length.


Cite This Page:

University Of Arkansas For Medical Sciences. "Scientists Activate Bone Cell Rescue Pathway." ScienceDaily. ScienceDaily, 12 March 2001. <www.sciencedaily.com/releases/2001/03/010309081500.htm>.
University Of Arkansas For Medical Sciences. (2001, March 12). Scientists Activate Bone Cell Rescue Pathway. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2001/03/010309081500.htm
University Of Arkansas For Medical Sciences. "Scientists Activate Bone Cell Rescue Pathway." ScienceDaily. www.sciencedaily.com/releases/2001/03/010309081500.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins