Featured Research

from universities, journals, and other organizations

Cancer Virus In Sheep May Provide Clues To Understanding Human Lung Cancer, According To Hutchinson Center Study

Date:
April 19, 2001
Source:
Fred Hutchinson Cancer Research Center
Summary:
A virus that causes contagious lung cancer in sheep may be instrumental in understanding a similar malignancy in humans that accounts for 25 percent of lung-cancer cases in the United States, according to researchers at the Fred Hutchinson Cancer Research Center and the National Cancer Institute.

SEATTLE - A virus that causes contagious lung cancer in sheep may be instrumental in understanding a similar malignancy in humans that accounts for 25 percent of lung-cancer cases in the United States, according to researchers at the Fred Hutchinson Cancer Research Center and the National Cancer Institute.

The results of the study, led by A. Dusty Miller, Ph.D., a member of the Hutchinson Center's Human Biology and Basic Sciences divisions, will be published tomorrow in the Proceedings of the National Academy of Sciences.

Miller and colleagues from the NCI report that the Jaagsiekte sheep retrovirus protein that promotes docking and entry into cells, called the envelope protein, can cause cancer-like changes in cultured cells. They also have identified the cell-surface molecule that interacts with the envelope protein and allows the virus to infiltrate cells, a key for understanding how the virus causes cancer. This receptor protein had been identified as a candidate tumor-suppressor protein in bronchioalveolar carcinoma, a non-smoking related lung cancer of unknown origin.

"This study provides the basis for further understanding of an important human cancer and also advances our efforts to develop this virus as a vehicle for transferring genes to the lung for gene therapy," said Miller, also an affiliate professor of pathology at the University of Washington School of Medicine.

"The use of a cancer-causing virus for gene therapy may seem contradictory, but if we can knock out the ability of the virus to cause cancer while preserving its ability to transfer genes to lung cells, such gene-therapy viruses may be very useful, especially for treating lung diseases such as cystic fibrosis."

A related paper in the same issue of PNAS by researchers from the University of California, Irvine, further explores the ability of the envelope protein to cause cancer.

Together, these two studies provide keys for better understanding the mechanism by which this sheep retrovirus causes cancer, as well as its relationship to human lung cancer.

The Hutchinson Center study was funded by grants from the National Institutes of Health.

The Fred Hutchinson Cancer Research Center is an independent, nonprofit research institution dedicated to the development and advancement of biomedical technology to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's four scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. For more information, visit the Center's Web site at http://www.fhcrc.org.


Story Source:

The above story is based on materials provided by Fred Hutchinson Cancer Research Center. Note: Materials may be edited for content and length.


Cite This Page:

Fred Hutchinson Cancer Research Center. "Cancer Virus In Sheep May Provide Clues To Understanding Human Lung Cancer, According To Hutchinson Center Study." ScienceDaily. ScienceDaily, 19 April 2001. <www.sciencedaily.com/releases/2001/04/010411083318.htm>.
Fred Hutchinson Cancer Research Center. (2001, April 19). Cancer Virus In Sheep May Provide Clues To Understanding Human Lung Cancer, According To Hutchinson Center Study. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2001/04/010411083318.htm
Fred Hutchinson Cancer Research Center. "Cancer Virus In Sheep May Provide Clues To Understanding Human Lung Cancer, According To Hutchinson Center Study." ScienceDaily. www.sciencedaily.com/releases/2001/04/010411083318.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins