Featured Research

from universities, journals, and other organizations

Genetically Engineered Poliovirus Fights Brain Tumors

Date:
May 22, 2001
Source:
American Society For Microbiology
Summary:
What do you get when you cross a poliovirus with the virus that causes the common cold? An efficient mechanism for killing brain tumors, say scientists at Duke University, who have successfully used the genetically modified poliovirus to cure brain tumors in mice.

What do you get when you cross a poliovirus with the virus that causes the common cold? An efficient mechanism for killing brain tumors, say scientists at Duke University, who have successfully used the genetically modified poliovirus to cure brain tumors in mice. They report their results at the 101st General Meeting of the American Society for Microbiology.

"Malignant glioma (the most common type of brain tumor) is almost always fatal, due to very poor response to surgery, radiation and chemotherapy," says Matthias Gromeier, in whose laboratory the research was conducted. "We have developed a new form of therapy against malignant glioma based on viruses that can cause brain infections in humans."

The creation of this new therapy began when Gromeier and his colleagues discovered that the molecule that the poliovirus binds to on human cells, CD155, is abnormally expressed on malignant gliomas. This meant that the poliovirus would naturally target brain tumors. Unfortunately, the use of the virus as a treatment was severely limited by its ability to cause polio in humans.

"We genetically engineered a poliovirus variant that lost its ability to cause disease in humans. We accomplished this task by inserting a piece of genetic information of rhinovirus (the virus that causes the common cold) into the poliovirus genome," says Gromeier. "The mixed polio/rhinovirus construct had very surprising properties: it had lost its ability to cause poliomyelitis in humans, but retained excellent killing potential for malignant glioma cells."

They tested the abilities of this new hybrid virus using mice with experimental brain tumors. The animals recovered after a single dose of the virus. "Pathological analysis of their brains revealed tumors to be eliminated by replicating virus within days," says Gromeier.

This research was conducted with support from the American Cancer Society, the National Cancer Institute and the Burroughs Wellcome Fund.


Story Source:

The above story is based on materials provided by American Society For Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society For Microbiology. "Genetically Engineered Poliovirus Fights Brain Tumors." ScienceDaily. ScienceDaily, 22 May 2001. <www.sciencedaily.com/releases/2001/05/010522073358.htm>.
American Society For Microbiology. (2001, May 22). Genetically Engineered Poliovirus Fights Brain Tumors. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2001/05/010522073358.htm
American Society For Microbiology. "Genetically Engineered Poliovirus Fights Brain Tumors." ScienceDaily. www.sciencedaily.com/releases/2001/05/010522073358.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins