Featured Research

from universities, journals, and other organizations

Homing In On Better Bone Marrow Transplants

Date:
June 26, 2001
Source:
Rockefeller University Press
Summary:
Researchers have identified a protein that allows cells to “home” to the bone marrow. The finding may allow clinicians to improve bone marrow transplantation by injecting only the cells needed to repopulate the bone marrow after chemotherapy.

Researchers have identified a protein that allows cells to “home” to the bone marrow. The finding may allow clinicians to improve bone marrow transplantation by injecting only the cells needed to repopulate the bone marrow after chemotherapy.

Robert Sackstein (Harvard Medical School, Boston, MA) and colleagues report in the June 11 issue of The Journal of Cell Biology that a sugar-coated variant of a protein called CD44 acts as the homing molecule for human hematopoietic progenitor cells (HPCs). The HPCs normally reside in bone marrow, and serve as the source of all new blood cells. HPCs also circulate in the bloodstream. They find their way back to the bone marrow by attaching to a protein called E-selectin, which is made by cells that line the blood vessels. The same mechanism allows cells in bone marrow transplants to find their way to their correct place in the bone marrow, even after the cells have been injected directly into the bloodstream.

Sackstein and colleagues set out to find the protein from HPCs that attaches to E-selectin. They found that the CD44 variant allowed cells to roll across or attach to a layer of tethered, E-selectin-containing cells, even as a jet of water was acting to displace the cells.

The variant is made only by HPCs, and not by more mature blood cells. This restricted production of the variant should allow Sackstein to isolate HPCs before doing a bone marrow transplant, thus reducing the number of cells given to transplant recipients. A purer transplant would give clinicians greater control over the immune reaction to a transplant, perhaps reducing the likelihood of graft-versus-host disease.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "Homing In On Better Bone Marrow Transplants." ScienceDaily. ScienceDaily, 26 June 2001. <www.sciencedaily.com/releases/2001/06/010612065343.htm>.
Rockefeller University Press. (2001, June 26). Homing In On Better Bone Marrow Transplants. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2001/06/010612065343.htm
Rockefeller University Press. "Homing In On Better Bone Marrow Transplants." ScienceDaily. www.sciencedaily.com/releases/2001/06/010612065343.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins