Featured Research

from universities, journals, and other organizations

USC Study Shows Raloxifene May Increase Ovarian Cancer Growth Rate

Date:
July 5, 2001
Source:
University Of Southern California
Summary:
The drug raloxifene may increase the growth rate of ovarian cancer and its risk of recurrence, according to researchers from the Keck School of Medicine of the University of Southern California.

LAUSANNE, SWITZERLAND, July 3 –– The drug raloxifene may increase the growth rate of ovarian cancer and its risk of recurrence, according to researchers from the Keck School of Medicine of the University of Southern California.

Speaking at the European Society of Human Reproduction and Embryology’s annual meeting, David Tourgeman, M.D., assistant professor of obstetrics and gynecology at the Keck School, presented data on the effects of raloxifene both alone and in combination with estradiol on ovarian cancer cell lines in the laboratory.

Raloxifene is a selective estrogen receptor modulator (SERM) that has been approved in the United States for use in patients with osteoporosis but has also been looked at as a possible agent for women needing estrogen replacement therapy (ERT). Past research has shown that raloxifene actually has antiestrogenic effects in human breast cancer cells, making it a potentially safe ERT alternative for women who have had breast cancer. In addition, it doesn’t seem to increase the risk of uterine cancer in postmenopausal women.

To date, however, not much work has been done on the drug’s affects on ovarian cancer, despite the fact that ovarian cancer, too, is a hormone-driven disease, noted Tourgeman.

Along with Richard Paulson, M.D., Keck School professor of obstetrics and gynecology, and their USC colleagues, Tourgeman found that both raloxifene and estradiol stimulate cell growth in ovarian adenocarcinoma cells that carried estrogen receptors on their cell surface (ER+ cells)—and that the drugs’ effects occur both when they are given independently and in combination. The cells were exposed to an amount of raloxifene equivalent to that which would be received by the usual 60 mg oral dose of the drug.

"To our knowledge, this is the first time that the effect of raloxifene on ovarian cell lines has been evaluated," said Tourgeman. He notes that there is an ongoing debate as to whether the presence of estrogen receptors on the tumor cells means that estrogen would necessarily cause an ovarian tumor to grow or reappear. Still, he says, "as up to 60 percent of epithelial ovarian cancers and a smaller percentage of anaplastic or recurrent ovarian cancers will be ER+, the most appropriate approach would be one of caution. In contrast to the clinical management of women with a history of breast cancer, raloxifene may not be a good alternative to ERT in women with ER+ ovarian cancer."

Both he and Paulson, however, stressed that this finding does not diminish the recognized benefits of ERT in general for strengthening bone, protecting the cardiovascular system and improving cognition.

That is why, Paulson says, "it would be premature to withhold all forms of ERT from patients with a history of ovarian cancer on the basis of these findings." He and Tourgeman intend to evaluate raloxifene in other cell types to see if it has similar effects. In addition, says Paulson, the hope is that this study will serve as an impetus to other researchers to undertake epidemiologic studies that would evaluate the possible association between raloxifene and ovarian cancer.


Story Source:

The above story is based on materials provided by University Of Southern California. Note: Materials may be edited for content and length.


Cite This Page:

University Of Southern California. "USC Study Shows Raloxifene May Increase Ovarian Cancer Growth Rate." ScienceDaily. ScienceDaily, 5 July 2001. <www.sciencedaily.com/releases/2001/07/010704092406.htm>.
University Of Southern California. (2001, July 5). USC Study Shows Raloxifene May Increase Ovarian Cancer Growth Rate. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2001/07/010704092406.htm
University Of Southern California. "USC Study Shows Raloxifene May Increase Ovarian Cancer Growth Rate." ScienceDaily. www.sciencedaily.com/releases/2001/07/010704092406.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins