Featured Research

from universities, journals, and other organizations

Mechanical Heart Pump Can Reverse Heart Failure

Date:
August 21, 2001
Source:
American Heart Association
Summary:
Left ventricular assist devices, or LVADs, used to mechanically pump blood through the hearts of individuals with heart failure as they await transplantation, can reverse reduced heart muscle performance, researchers report in Circulation: Journal of the American Heart Association.

DALLAS, Aug. 21 – Left ventricular assist devices, or LVADs, used to mechanically pump blood through the hearts of individuals with heart failure as they await transplantation, can reverse reduced heart muscle performance, researchers report in today’s Circulation: Journal of the American Heart Association.

This finding sheds new light on the commonly held theory that heart failure is an end-stage disease, with the only option for patients being a heart transplant, say the study researchers.

The study was among the first to look at beta-adrenergic receptor density and inotropic responsiveness to beta-adrenergic stimulation – the mechanisms that control the heart’s ability to contract in times of stress. In individuals with heart failure, both functions are blunted.

Researchers found that with the aid of an LVAD, these hallmarks of heart failure are reversible.

An LVAD is a mechanical pump-type device that is surgically implanted to augment the heart’s pumping ability. It can “buy time” for an individual waiting for a heart transplant and is often referred to as a “bridge to transplant.”

Researchers obtained non-failing human hearts from 15 organ donors whose hearts were unsuitable for transplantation but who had no history of cardiac disease. They obtained failing human hearts from 23 transplant patients who had not been supported with an LVAD and 19 patients who had been supported with an LVAD. The researchers used two methods in the study. They dissected muscle tissue from the hearts to compare cardiac muscle contractility at baseline and after stimulation by the drug isoproterenol. They also measured the density of beta-adrenergic receptors in non-failing human hearts and failing human hearts with or without LVAD. Results showed a significant increase in the response to beta-adrenergic stimulation after LVAD and an increased density of beta-adrenergic receptors, which indicate improved muscle performance.

Nearly 5 million Americans are living with heart failure. There are about 550,000 new cases diagnosed each year while the number of heart donors remains unchanged, according to the researchers. They say that more studies need to be done in order to determine whether the LVAD or other medical or surgical therapies could replace the need for heart transplants.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Mechanical Heart Pump Can Reverse Heart Failure." ScienceDaily. ScienceDaily, 21 August 2001. <www.sciencedaily.com/releases/2001/08/010821080132.htm>.
American Heart Association. (2001, August 21). Mechanical Heart Pump Can Reverse Heart Failure. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2001/08/010821080132.htm
American Heart Association. "Mechanical Heart Pump Can Reverse Heart Failure." ScienceDaily. www.sciencedaily.com/releases/2001/08/010821080132.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins