Featured Research

from universities, journals, and other organizations

Drug Decreases Blood Vessel Stiffness In Older People

Date:
September 4, 2001
Source:
NIH/National Institute On Aging
Summary:
A novel drug that breaks down collagen bonds in the body’s blood vessels significantly decreases the stiffness of vessels in older people, according to a study conducted by National Institute on Aging (NIA) scientists and others. The finding suggests the medication could be a new treatment for high blood pressure, heart failure, and certain complications of diabetes.

A novel drug that breaks down collagen bonds in the body’s blood vessels significantly decreases the stiffness of vessels in older people, according to a study conducted by National Institute on Aging (NIA) scientists and others.* The finding suggests the medication could be a new treatment for high blood pressure, heart failure, and certain complications of diabetes.

ALT-711 (Alteon, Ramsey, New Jersey), a thiazolium-based compound, snips bonds or crosslinks created in the arteries and other tissues when glucose attaches to the protein collagen. Crosslinks are cable-like structures that inhibit the natural flexibility of collagen strands. They tend to proliferate with age. Crosslinks appear to toughen tissues and may contribute to some of the deterioration associated with aging and diabetes, such as elevated systolic blood pressure, stiff arteries, and impaired kidney function.

Independent data from the NIA’s Baltimore Longitudinal Study of Aging identifies vascular stiffness as perhaps the most important predictor of mortality from heart disease. The ability to reduce vascular stiffness could have a major influence on reducing deaths from heart disease.

For the study, investigators at nine U.S. clinical centers recruited 93 people over the age of 50 who showed evidence of vascular stiffening, including high systolic blood pressure (greater than 140 mm Hg) and pulse pressure of at least 60 mm Hg.

The participants were randomly divided into two groups—those who received daily doses of ALT-711 and those who were given a placebo daily. After 56 days, arterial pulse pressure—the difference between systolic and diastolic blood pressures—was significantly reduced among those taking the drug compared to the placebo group. In addition, large artery compliance, a measure of artery wall flexibility and blood volume capacity, improved 15 percent in the ALT-711 group compared to no improvement in the placebo group.

No significant drug side effects were noted in the study. Participants in the study who were taking medications to treat high blood pressure were allowed to continue taking these drugs as long as these treatments began at least four weeks before the study commenced and remained unchanged throughout the trial.

The study will appear online Monday at http://circ.ahajournals.org/rapidtrack.shtml as a "Rapid Track" publication of Circulation: Journal of the American Heart Association. The manuscript will be published in the Sept. 25th issue of the journal.

“Arterial stiffening is a major factor in many of the vascular diseases associated with advancing age,” said Edward Lakatta, M.D., co-author of the study and chief of the NIA’s Laboratory of Cardiovascular Sciences. “The significance of this drug is it alters the properties of the arterial wall and makes it easier for the heart to eject blood into the blood vessels. These results, coupled with prior studies in animals, certainly suggest that ALT-711 may be a safe and efficacious approach to decreasing the impact of arterial stiffness on cardiovascular health.”

The research was a joint effort by the NIA, Johns Hopkins University, and Alteon, Inc., as part of the Cooperative Research and Development Act, and was conducted in conjunction with multiple medical institutions.

The National Institute on Aging, one of 25 Institutes that constitute the National Institutes of Health, leads Federal efforts to support and conduct basic, clinical, epidemiological, and social research on aging and the special needs of older people. For more information about the NIA, visit the website at http://www.nih.gov/nia

*D.A. Kass, E.P. Shapiro, M. Kawaguchi, A.R. Capriotti, A. Scuteri, R.C. deGroof, and E.G. Lakatta, “Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker,” Circulation, 2001;104:r8-r14. A. Capriotti and Drs. Kass, Shapiro, and Kawaguchi are affiliated with Johns Hopkins Medical Institutions, Baltimore; Dr. Scuteri and Lakatta are affiliated with the Gerontology Research Center, National Institute on Aging, Baltimore; Dr. deGroof is employed by Alteon, Ramsey, N.J.


Story Source:

The above story is based on materials provided by NIH/National Institute On Aging. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute On Aging. "Drug Decreases Blood Vessel Stiffness In Older People." ScienceDaily. ScienceDaily, 4 September 2001. <www.sciencedaily.com/releases/2001/09/010904072709.htm>.
NIH/National Institute On Aging. (2001, September 4). Drug Decreases Blood Vessel Stiffness In Older People. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2001/09/010904072709.htm
NIH/National Institute On Aging. "Drug Decreases Blood Vessel Stiffness In Older People." ScienceDaily. www.sciencedaily.com/releases/2001/09/010904072709.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins