Featured Research

from universities, journals, and other organizations

Amphetamines Paired With Therapy May Relieve Stroke-Related Speech Problems, Researchers Report

Date:
September 10, 2001
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
Stroke patients who take an amphetamine before speech-language therapy regain their speech at a faster rate than patients who go through speech-language therapy without the drugs, UT Southwestern Medical Center at Dallas researchers report.

DALLAS - Sept. 7, 2001 - Stroke patients who take an amphetamine before speech-language therapy regain their speech at a faster rate than patients who go through speech-language therapy without the drugs, UT Southwestern Medical Center at Dallas researchers report.

In the Sept. 7 issue of Stroke: Journal of the American Heart Association, Dr. Hal Unwin, associate professor of neurology and director of UT Southwestern's stroke program, reports that patients with aphasia, or the loss of language and communications skills, recover more speech and language faster if given a low-dose amphetamine half an hour before speech-language therapy.

"Aphasia is one of the most common side effects of stroke, and it is caused by a direct injury to the language center in the brain," said Unwin. "Speeding up the patients' rate of recovery is vitally important."

Unwin and his colleagues studied 21 patients with aphasia caused by stroke. Patients entered the double-blind study between 16 to 45 days after their stroke. All patients received speech and language therapy in 10 one-hour sessions over five weeks. Some patients received dextroamphetamine 30 minutes before each speech-therapy session, and some patients received a placebo before their sessions.

Dr. Delaina Walker-Batson, clinical associate professor of radiology and neurology at UT Southwestern and professor of communication sciences and disorders at Texas Woman's University, was lead author of the paper.

"This is not a panacea. Patients recover some speech skills depending on the severity of the stroke," she said. "We have studied some very severely affected patients who have had an increase in both the rate and extent of their recovery with the drug and therapy combination.

Because patients receive less rehabilitation now, drugs can be an important addition to their rehabilitation. If you can communicate very little and you recover enough language to go to a restaurant and order, it really changes your quality of life."

UT Southwestern researchers have been testing amphetamines paired with physical and speech therapy in stroke patients for several years. They theorize the drug may work by releasing a neurotransmitter called noradrenaline, which may help a stroke patient's brain cells wake up and be more responsive. Noradrenaline is known to be involved in learning and memory.

Previous studies, including one published by Unwin, Walker-Batson and Patricia Smith, UT Southwestern assistant professor of physical therapy, in Stroke in 1995, have shown the drug can have an effect on motor skills. In their 1995 study, the researchers paired administration of dextroamphetamine with physical therapy. Patients recovered at a greater rate with the drug and physical therapy than with physical therapy alone. And in 2000, Unwin and Walker-Batson reported that patients who received the dextroamphetamine suffered no adverse reactions.

"It's not the drug alone, it's the drug paired with treatment," Walker-Batson said. "There's a natural plasticity in the brain, and the drug seems to recruit parts of the brain that haven't been used before."

Stroke is one of the leading causes of adult disability, and 4 million Americans are living with the effects of a stroke. According to the National Stroke Association, stroke is the nation's third leading cause of death, killing nearly 160,000 Americans every year.

Researchers from Texas Woman's University, Southern Methodist University, UT Health Science Center at Houston and the Veterans Affairs Northern California Health Care System participated in the study.

The study was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "Amphetamines Paired With Therapy May Relieve Stroke-Related Speech Problems, Researchers Report." ScienceDaily. ScienceDaily, 10 September 2001. <www.sciencedaily.com/releases/2001/09/010907081528.htm>.
University Of Texas Southwestern Medical Center At Dallas. (2001, September 10). Amphetamines Paired With Therapy May Relieve Stroke-Related Speech Problems, Researchers Report. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2001/09/010907081528.htm
University Of Texas Southwestern Medical Center At Dallas. "Amphetamines Paired With Therapy May Relieve Stroke-Related Speech Problems, Researchers Report." ScienceDaily. www.sciencedaily.com/releases/2001/09/010907081528.htm (accessed August 22, 2014).

Share This




More Mind & Brain News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins