Featured Research

from universities, journals, and other organizations

Researchers Develop Specialized Cell Types From Embryonic Monkey Stem Cells

Date:
February 1, 2002
Source:
Wake Forest University Baptist Medical Center
Summary:
Researchers from Wake Forest University School of Medicine and Advanced Cell Technology (ACT) of Worcester, Mass. report in today's Science that they have developed a large variety of specialized cell types -- including heart and brain cells -- from embryonic monkey stem cells through a process called parthenogenesis.

Researchers from Wake Forest University School of Medicine and Advanced Cell Technology (ACT) of Worcester, Mass. report in today's Science that they have developed a large variety of specialized cell types -- including heart and brain cells -- from embryonic monkey stem cells through a process called parthenogenesis. The researchers reported that they had generated a "pluripotent" stem cell line that they called cyno-1 (so named for the species of monkey). From that cell line, they already have produced brain neurons, heart muscle, smooth muscle, beating ciliated epithelial cells and a number of other kinds of cells, demonstrating, they said, "broad differentiation capabilities of primate stem cells derived by parthenogenesis."

Related Articles


The cell line has grown continuously for 10 months.

The stem cell line was produced by collaboration between researchers from ACT, led by Jose Cibelli, Ph.D. and Michael West, Ph.D., Wake Forest researchers Kathleen A. Grant, Ph.D. and Kent E. Vrana, Ph.D., Sloan Kettering Cancer Center (Lorenz Studer, M.D.), and the Mayo Clinic (Peter Wettstein, Ph.D.).

Grant and Vrana, both professors of physiology and pharmacology, said the most remarkable differentiation was the development of midbrain dopamine neurons. "This is a specialized population of neurons whose efficient generation from primate embryonic stem cells had not been reported previously."

"The potential clinical applications include treatment of diseases where specific cell types have become dysfunctional. These diseases include a broad array of medical problems, such as Parkinson's and Huntington's diseases, heart disease and diabetes," West said. The parthenogenetic process leads to stem cells without creating embryos that normally require an egg from the mother and a sperm from the father. Parthenogenesis is defined as a process by which embryonic development is initiated directly from an unfertilized egg cell.

Parthenogenesis results in a microscopic ball of cells, called a blastocyst, typically 50 to 200 cells. When an egg is fertilized by sperm in the body or in vitro, it can then grow into a fetus. But the blastocyst that results from parthenogenesis does not become a viable fetus.

The cyno-1 stem cell line was developed from this reproductively non-viable blastocyst. "Neurons and other cells derived from this renewable source could alleviate some of the technical problems of human cell therapy," Cibelli said, "including rejection of transplanted tissue."

Vrana said, "Parthenogenesis offers an important new therapeutic strategy for a host of medical conditions." However, all of the researchers emphasized that human clinical applications will require years of further research and development.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Researchers Develop Specialized Cell Types From Embryonic Monkey Stem Cells." ScienceDaily. ScienceDaily, 1 February 2002. <www.sciencedaily.com/releases/2002/02/020201075911.htm>.
Wake Forest University Baptist Medical Center. (2002, February 1). Researchers Develop Specialized Cell Types From Embryonic Monkey Stem Cells. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2002/02/020201075911.htm
Wake Forest University Baptist Medical Center. "Researchers Develop Specialized Cell Types From Embryonic Monkey Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2002/02/020201075911.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) — Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) — If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) — GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) — How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins