Featured Research

from universities, journals, and other organizations

Researchers Develop Specialized Cell Types From Embryonic Monkey Stem Cells

Date:
February 1, 2002
Source:
Wake Forest University Baptist Medical Center
Summary:
Researchers from Wake Forest University School of Medicine and Advanced Cell Technology (ACT) of Worcester, Mass. report in today's Science that they have developed a large variety of specialized cell types -- including heart and brain cells -- from embryonic monkey stem cells through a process called parthenogenesis.

Researchers from Wake Forest University School of Medicine and Advanced Cell Technology (ACT) of Worcester, Mass. report in today's Science that they have developed a large variety of specialized cell types -- including heart and brain cells -- from embryonic monkey stem cells through a process called parthenogenesis. The researchers reported that they had generated a "pluripotent" stem cell line that they called cyno-1 (so named for the species of monkey). From that cell line, they already have produced brain neurons, heart muscle, smooth muscle, beating ciliated epithelial cells and a number of other kinds of cells, demonstrating, they said, "broad differentiation capabilities of primate stem cells derived by parthenogenesis."

The cell line has grown continuously for 10 months.

The stem cell line was produced by collaboration between researchers from ACT, led by Jose Cibelli, Ph.D. and Michael West, Ph.D., Wake Forest researchers Kathleen A. Grant, Ph.D. and Kent E. Vrana, Ph.D., Sloan Kettering Cancer Center (Lorenz Studer, M.D.), and the Mayo Clinic (Peter Wettstein, Ph.D.).

Grant and Vrana, both professors of physiology and pharmacology, said the most remarkable differentiation was the development of midbrain dopamine neurons. "This is a specialized population of neurons whose efficient generation from primate embryonic stem cells had not been reported previously."

"The potential clinical applications include treatment of diseases where specific cell types have become dysfunctional. These diseases include a broad array of medical problems, such as Parkinson's and Huntington's diseases, heart disease and diabetes," West said. The parthenogenetic process leads to stem cells without creating embryos that normally require an egg from the mother and a sperm from the father. Parthenogenesis is defined as a process by which embryonic development is initiated directly from an unfertilized egg cell.

Parthenogenesis results in a microscopic ball of cells, called a blastocyst, typically 50 to 200 cells. When an egg is fertilized by sperm in the body or in vitro, it can then grow into a fetus. But the blastocyst that results from parthenogenesis does not become a viable fetus.

The cyno-1 stem cell line was developed from this reproductively non-viable blastocyst. "Neurons and other cells derived from this renewable source could alleviate some of the technical problems of human cell therapy," Cibelli said, "including rejection of transplanted tissue."

Vrana said, "Parthenogenesis offers an important new therapeutic strategy for a host of medical conditions." However, all of the researchers emphasized that human clinical applications will require years of further research and development.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Researchers Develop Specialized Cell Types From Embryonic Monkey Stem Cells." ScienceDaily. ScienceDaily, 1 February 2002. <www.sciencedaily.com/releases/2002/02/020201075911.htm>.
Wake Forest University Baptist Medical Center. (2002, February 1). Researchers Develop Specialized Cell Types From Embryonic Monkey Stem Cells. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2002/02/020201075911.htm
Wake Forest University Baptist Medical Center. "Researchers Develop Specialized Cell Types From Embryonic Monkey Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2002/02/020201075911.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) — Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) — A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) — Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins