Featured Research

from universities, journals, and other organizations

Finding Out What's Right May Benefit Dogs And Cats With Diabetes

Date:
March 1, 2002
Source:
Kansas State University
Summary:
When something is broken, you may first have to find out how it functions properly to fix it. A Kansas State University researcher is using that idea to see what is wrong or different in animals with diabetes versus those that are normal. Thomas Schermerhorn, assistant professor of clinical sciences, is involved in research that may be applied to diabetes in dogs and cats, as well as humans.

MANHATTAN - When something is broken, you may first have to find out how it functions properly to fix it.A Kansas State University researcher is using that idea to see what is wrong or different in animals with diabetes versus those that are normal.

Thomas Schermerhorn, assistant professor of clinical sciences, is involved in research that may be applied to diabetes in dogs and cats, as well as humans.

"We know what goes wrong in diabetes, but we don't know why it goes wrong. Our approach looks at what is normal and compares that to an abnormal cell to find out where the problem is," Schermerhorn said.

Schermerhorn's research focuses on the functions of the beta cell, the cell in the pancreas that secretes insulin. There are thousands of beta cells, each one with tiny granules containing small amounts of insulin. The granules go to the cell membrane and stay there until receiving the proper stimulus, Schermerhorn said.

"Each granule has a tiny amount of insulin, each one secreting insulin resulting in a normal response after eating a meal. This lowers blood sugar and keeps it under control," Schermerhorn said.

The beta cells Schermerhorn studies are altered so they are capable of reproducing outside the body yet can still secrete insulin. These cells act exactly like beta cells that live inside normal animals and humans, Schermerhorn said.

Schermerhorn began by looking at inhibitors of insulin and found that once the beta cell was stimulated to secrete insulin, it could then be modified by inhibitors. The inhibitors tend to decrease cell response to glucose, the principal nutrient in a diet that stimulates secretion.

Norepinephrine, an inhibitor sometimes called noradrenaline, can inhibit secretion profoundly and has direct effects on the proteins in the final stage of granule release, Schermerhorn said.

"Norepinephrine somehow alters or impairs three crucial proteins from coming together. This either disables the granule from being secreted, or prevents the granule from coming to the membrane and forming a protein complex," Schermerhorn said.

Diabetes is the second most common endocrine problem of older cats and one of the top three endocrine problems of older dogs.

Weight loss, excessive water consumption and excessive urination are common symptoms in dogs or cats indicating they may need to be tested for diabetes, Schermerhorn said.

"Usually, the dog or cat maintains an excellent appetite although they do not gain weight, but instead they may lose weight," Schermerhorn said.

"We're hoping to use a physiological approach to learn about beta cell function and provide a basis for the study of abnormal beta cell function that might contribute to the development of diabetes," Schermerhorn said.

Schermerhorn's research is in collaboration with Geoffrey Sharp, department of molecular medicine in the College of Veterinary Medicine at Cornell University, and Philine Wangemann, department of anatomy and physiology at K-State's College of Veterinary Medicine.

The research project is funded by a grant from the National Institute of Diabetes, Digestive and Kidney Diseases of the National Institutes of Health.


Story Source:

The above story is based on materials provided by Kansas State University. Note: Materials may be edited for content and length.


Cite This Page:

Kansas State University. "Finding Out What's Right May Benefit Dogs And Cats With Diabetes." ScienceDaily. ScienceDaily, 1 March 2002. <www.sciencedaily.com/releases/2002/03/020301071619.htm>.
Kansas State University. (2002, March 1). Finding Out What's Right May Benefit Dogs And Cats With Diabetes. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2002/03/020301071619.htm
Kansas State University. "Finding Out What's Right May Benefit Dogs And Cats With Diabetes." ScienceDaily. www.sciencedaily.com/releases/2002/03/020301071619.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins