Featured Research

from universities, journals, and other organizations

MGH Researchers Unravel Structure Of A Key Protein Involved In Tumor Angiogenesis And Metastasis

Date:
March 13, 2002
Source:
Massachusetts General Hospital
Summary:
Cancer cells need a blood supply to grow. A key receptor protein called the alpha V beta 3 integrin directs formation of new blood vessels by binding to other proteins, such as angiostatin and endostatin, produced by tumor cells. Scientists at Massachusetts General Hospital (MGH) have now deciphered the detailed structure of this protein as it interacts with its ligand (the protein that binds to a receptor). The work comes on the heels of findings published last year by the MGH investigators on the structure of the same protein in its resting unbound state.

Cancer cells need a blood supply to grow. A key receptor protein called the alpha V beta 3 integrin directs formation of new blood vessels by binding to other proteins, such as angiostatin and endostatin, produced by tumor cells. Scientists at Massachusetts General Hospital (MGH) have now deciphered the detailed structure of this protein as it interacts with its ligand (the protein that binds to a receptor). The work comes on the heels of findings published last year by the MGH investigators on the structure of the same protein in its resting unbound state. The new data, which will appear in a future issue of Science, are being published March 7 on the Science Express website (http://www.sciencexpress.org).

Related Articles


"By knowing the intricate molecular interactions between this receptor and its ligand, we are now in a better position to devise inhibitors that block this interaction and therefore prevent or forestall tumor angiogenesis and progression," says M. Amin Arnaout, MD, senior author, director of the MGH Structural Biology Program and chief of the MGH Renal Unit. Arnaout says this integrin receptor is also used by breast cancer cells to escape into the bloodstream and metastasize. "With this new information, we might be able to intercept that process as well," says Arnaout.

The MGH scientists also found that alpha V beta 3 integrin changes its shape when bound to its ligand, allowing it to send chemical signals instructing tumor cells to grow and spread. "Defining this shape-shift at the atomic level may also be harnessed therapeutically by designing more selective drugs with fewer side effects," says Arnaout.

There are 23 additional integrin receptors in humans, all with similar structural motifs. Some of these play important roles in other diseases -- such as osteoporosis, stroke, heart attack, diabetes, nephritis and rheumatoid arthritis -- and all bind to their protein ligands in a similar manner. "Catching an integrin in the act of binding to its ligand will offer new means of developing drugs to other debilitating diseases besides cancer," says Arnaout.

The other members of the research team include Jian-Ping Xiong, PhD, and Thilo Stehle, PhD, of the MGH -- who along with Arnaout are members of the MGH Structural Biology Program -- Matthias Frech, PhD, and Simon Goodman, PhD, of Merck KGaA in Germany, and Rongguang Zhang, PhD, and Andrzej Joachimiak, PhD, of the Argonne National Laboratory in Illinois. The study was supported by research grants from the National Institutes of Health and the U.S. Department of Energy.

The Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $300 million and major research centers in AIDS, the neurosciences, cardiovascular research, cancer, cutaneous biology, transplantation biology and photomedicine. In 1994, the MGH joined with Brigham and Women's Hospital to form Partners HealthCare System, an integrated health care delivery system comprising the two academic medical centers, specialty and community hospitals, a network of physician groups and nonacute and home health services.


Story Source:

The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts General Hospital. "MGH Researchers Unravel Structure Of A Key Protein Involved In Tumor Angiogenesis And Metastasis." ScienceDaily. ScienceDaily, 13 March 2002. <www.sciencedaily.com/releases/2002/03/020311080220.htm>.
Massachusetts General Hospital. (2002, March 13). MGH Researchers Unravel Structure Of A Key Protein Involved In Tumor Angiogenesis And Metastasis. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2002/03/020311080220.htm
Massachusetts General Hospital. "MGH Researchers Unravel Structure Of A Key Protein Involved In Tumor Angiogenesis And Metastasis." ScienceDaily. www.sciencedaily.com/releases/2002/03/020311080220.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins