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MGH Researchers Unravel Structure Of A Key Protein Involved In Tumor Angiogenesis And Metastasis

Date:
March 13, 2002
Source:
Massachusetts General Hospital
Summary:
Cancer cells need a blood supply to grow. A key receptor protein called the alpha V beta 3 integrin directs formation of new blood vessels by binding to other proteins, such as angiostatin and endostatin, produced by tumor cells. Scientists at Massachusetts General Hospital (MGH) have now deciphered the detailed structure of this protein as it interacts with its ligand (the protein that binds to a receptor). The work comes on the heels of findings published last year by the MGH investigators on the structure of the same protein in its resting unbound state.

Cancer cells need a blood supply to grow. A key receptor protein called the alpha V beta 3 integrin directs formation of new blood vessels by binding to other proteins, such as angiostatin and endostatin, produced by tumor cells. Scientists at Massachusetts General Hospital (MGH) have now deciphered the detailed structure of this protein as it interacts with its ligand (the protein that binds to a receptor). The work comes on the heels of findings published last year by the MGH investigators on the structure of the same protein in its resting unbound state. The new data, which will appear in a future issue of Science, are being published March 7 on the Science Express website (http://www.sciencexpress.org).


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The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


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Massachusetts General Hospital. "MGH Researchers Unravel Structure Of A Key Protein Involved In Tumor Angiogenesis And Metastasis." ScienceDaily. ScienceDaily, 13 March 2002. <www.sciencedaily.com/releases/2002/03/020311080220.htm>.
Massachusetts General Hospital. (2002, March 13). MGH Researchers Unravel Structure Of A Key Protein Involved In Tumor Angiogenesis And Metastasis. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2002/03/020311080220.htm
Massachusetts General Hospital. "MGH Researchers Unravel Structure Of A Key Protein Involved In Tumor Angiogenesis And Metastasis." ScienceDaily. www.sciencedaily.com/releases/2002/03/020311080220.htm (accessed April 20, 2014).

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