Featured Research

from universities, journals, and other organizations

Clotting Cells Switched On By Cold

Date:
March 20, 2002
Source:
University Of California - Davis
Summary:
Platelets, the cells that make blood clot, are in high demand from blood banks. Blood banks store them at room temperature and throw them out after five days. They would last longer refrigerated, but if you chill platelets, they activate and form a useless clot in the bag. Researchers have now shown that a key step for that activation is the formation of "lipid raft" structures in the membranes enclosing the cells.

Platelets, the cells that make blood clot, are in high demand from blood banks. Blood banks store them at room temperature and throw them out after five days. They would last longer refrigerated, but if you chill platelets, they activate and form a useless clot in the bag. Researchers have now shown that a key step for that activation is the formation of "lipid raft" structures in the membranes enclosing the cells.

Related Articles


Discovering how and why platelets get activated is also important for understanding how blood clots can cause heart attacks and strokes.

Karine Gousset and colleagues from the University of California, Davis, Biostabilization Laboratory, led by John Crowe and Fern Tablin, have shown that chilling causes changes in the platelets' outer membrane. At body temperature, cell membranes are fairly fluid, like a soap bubble. The fatty molecules that make up the membrane can jostle and move around next to each other.

When the temperature drops, some of the molecules in the membrane, such as cholesterol and another molecule called sphingomyelin, clump into distinct islands in the membrane called "lipid rafts." Some proteins attached to the surface, including some that carry signals from the cell surface to the inside, are also collected into these rafts.

After rafts form, the cells show other signs of activation, such as increased calcium levels, Crowe said. Platelets respond to other signals in the same way, showing that lipid raft formation is a general first step in platelet activation, Crowe said.


Story Source:

The above story is based on materials provided by University Of California - Davis. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Davis. "Clotting Cells Switched On By Cold." ScienceDaily. ScienceDaily, 20 March 2002. <www.sciencedaily.com/releases/2002/03/020320081951.htm>.
University Of California - Davis. (2002, March 20). Clotting Cells Switched On By Cold. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2002/03/020320081951.htm
University Of California - Davis. "Clotting Cells Switched On By Cold." ScienceDaily. www.sciencedaily.com/releases/2002/03/020320081951.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins