Featured Research

from universities, journals, and other organizations

Clotting Cells Switched On By Cold

Date:
March 20, 2002
Source:
University Of California - Davis
Summary:
Platelets, the cells that make blood clot, are in high demand from blood banks. Blood banks store them at room temperature and throw them out after five days. They would last longer refrigerated, but if you chill platelets, they activate and form a useless clot in the bag. Researchers have now shown that a key step for that activation is the formation of "lipid raft" structures in the membranes enclosing the cells.

Platelets, the cells that make blood clot, are in high demand from blood banks. Blood banks store them at room temperature and throw them out after five days. They would last longer refrigerated, but if you chill platelets, they activate and form a useless clot in the bag. Researchers have now shown that a key step for that activation is the formation of "lipid raft" structures in the membranes enclosing the cells.

Discovering how and why platelets get activated is also important for understanding how blood clots can cause heart attacks and strokes.

Karine Gousset and colleagues from the University of California, Davis, Biostabilization Laboratory, led by John Crowe and Fern Tablin, have shown that chilling causes changes in the platelets' outer membrane. At body temperature, cell membranes are fairly fluid, like a soap bubble. The fatty molecules that make up the membrane can jostle and move around next to each other.

When the temperature drops, some of the molecules in the membrane, such as cholesterol and another molecule called sphingomyelin, clump into distinct islands in the membrane called "lipid rafts." Some proteins attached to the surface, including some that carry signals from the cell surface to the inside, are also collected into these rafts.

After rafts form, the cells show other signs of activation, such as increased calcium levels, Crowe said. Platelets respond to other signals in the same way, showing that lipid raft formation is a general first step in platelet activation, Crowe said.


Story Source:

The above story is based on materials provided by University Of California - Davis. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Davis. "Clotting Cells Switched On By Cold." ScienceDaily. ScienceDaily, 20 March 2002. <www.sciencedaily.com/releases/2002/03/020320081951.htm>.
University Of California - Davis. (2002, March 20). Clotting Cells Switched On By Cold. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2002/03/020320081951.htm
University Of California - Davis. "Clotting Cells Switched On By Cold." ScienceDaily. www.sciencedaily.com/releases/2002/03/020320081951.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins