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Study Finds Widespread Sympathetic Nerve Damage In Parkinson's Disease

Date:
April 23, 2002
Source:
NIH/National Institute Of Neurological Disorders And Stroke
Summary:
For years, researchers have known that the symptoms of Parkinson's disease (PD) result from damage to a specific region of the brain. A new study shows that the disease also causes widespread damage to the sympathetic nervous system, which controls blood pressure, pulse rate, perspiration, and many other automatic responses to stress. The findings help explain the blood pressure regulation problems commonly found in PD and may lead to new treatments for the disease.

For years, researchers have known that the symptoms of Parkinson's disease (PD) result from damage to a specific region of the brain. A new study shows that the disease also causes widespread damage to the sympathetic nervous system, which controls blood pressure, pulse rate, perspiration, and many other automatic responses to stress. The findings help explain the blood pressure regulation problems commonly found in PD and may lead to new treatments for the disease. Physicians have long known that patients with PD often have incontinence and other symptoms of autonomic nervous system function, and previous studies have found evidence of sympathetic nerve damage in PD patients' hearts. The sympathetic nervous system is one component of the autonomic nervous system. However, this study is the first to show that the disease affects sympathetic nerve endings in the thyroid gland and the kidney, says David S. Goldstein, M.D., Ph.D., of the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland, who led the study. It also shows that this damage is unrelated to treatment with the most commonly used Parkinson's drug, levodopa. The study appears in the April 23, 2002, issue of Neurology.*


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The above story is based on materials provided by NIH/National Institute Of Neurological Disorders And Stroke. Note: Materials may be edited for content and length.


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NIH/National Institute Of Neurological Disorders And Stroke. "Study Finds Widespread Sympathetic Nerve Damage In Parkinson's Disease." ScienceDaily. ScienceDaily, 23 April 2002. <www.sciencedaily.com/releases/2002/04/020423080758.htm>.
NIH/National Institute Of Neurological Disorders And Stroke. (2002, April 23). Study Finds Widespread Sympathetic Nerve Damage In Parkinson's Disease. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2002/04/020423080758.htm
NIH/National Institute Of Neurological Disorders And Stroke. "Study Finds Widespread Sympathetic Nerve Damage In Parkinson's Disease." ScienceDaily. www.sciencedaily.com/releases/2002/04/020423080758.htm (accessed April 16, 2014).

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