Featured Research

from universities, journals, and other organizations

Key Powerhouse Enzyme Linked To Cancer Development

Date:
May 14, 2002
Source:
Johns Hopkins Medical Institutions
Summary:
Scientists at the Johns Hopkins Kimmel Cancer Center have discovered that an enzyme found in a tumor cell's energy center has a special relationship with a gene that controls cancer cell growth and death. Their findings, published in the May 14 issue of the Proceedings of the National Academy of Sciences, may offer a road map to anti-cancer therapies designed to manipulate the genetic pathway that switches the enzyme on and off.

Scientists at the Johns Hopkins Kimmel Cancer Center have discovered that an enzyme found in a tumor cell's energy center has a special relationship with a gene that controls cancer cell growth and death. Their findings, published in the May 14 issue of the Proceedings of the National Academy of Sciences, may offer a road map to anti-cancer therapies designed to manipulate the genetic pathway that switches the enzyme on and off.

Related Articles


The enzyme PRDX3 inhabits mitochondria, the tiny organelles that provide energy to cells and a meeting ground for regulation of cell life and death. "What this research suggests is that we might be able to shut down tumors by learning how to control this enzyme," says Chi Dang, M.D., Ph.D., director of the division of hematology and professor of medicine, cell biology, pathology and oncology.

Proteins made by the PRDX3 gene, known to be overexpressed in breast cancer, chew up or reduce oxidants, called peroxides entering the cell. Hopkins investigators used a scanning method to "skip" through pieces of the PRDX3 gene and precisely pinpoint areas where certain proteins bind to it, acting like ignition switches to increase expression. The investigators found that a key ignition switch controlling activation of PRDX3 is a well-known cell growth-promoting cancer gene called c-MYC.

To find out how c-MYC and PRDX3 work together, the scientists looked at different levels of PRDX3 activation in rat and human cancer cell lines where c-MYC was turned on. When they shut down PRDX3, turning off its ability to make its enzyme, the mouse tumors stopped growing. When they turned it back on, tumors grew rapidly.

"Think of PRDX3 as a light bulb and c-myc as the light switch. If you remove the light bulb even though the switch may be on, the lamp still doesn't work," explains Dr. Dang. "In this case, we've removed the light bulb rendering the switch powerless."

"These results show that changing PRDX3 activation can alter how tumors grow. Now, our challenge is to find out in which cancers this pathway is most important and what drugs may do the job," says Dr. Dang.

This research was funded by the National Cancer Institute, National Institutes of Health.

Other participants in this research were Diane Wonsey and Karen Zeller of Johns Hopkins.

Reference: Diane R. Wonsey, Karen I. Zeller, and Chi V. Dang, "The c-MYC target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation," Proceedings of the National Academy of Sciences, May 2002, Vol. 99, Issue 10: pp. 6649-6654.

On the Web:

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins: http://www.hopkinskimmelcancercenter.org


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Key Powerhouse Enzyme Linked To Cancer Development." ScienceDaily. ScienceDaily, 14 May 2002. <www.sciencedaily.com/releases/2002/05/020514072225.htm>.
Johns Hopkins Medical Institutions. (2002, May 14). Key Powerhouse Enzyme Linked To Cancer Development. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2002/05/020514072225.htm
Johns Hopkins Medical Institutions. "Key Powerhouse Enzyme Linked To Cancer Development." ScienceDaily. www.sciencedaily.com/releases/2002/05/020514072225.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins