Featured Research

from universities, journals, and other organizations

Adult Bone Marrow Stem Cells Can Become Liver Cells, Minnesota Researchers Report

Date:
May 15, 2002
Source:
University Of Minnesota
Summary:
Researchers at the University of Minnesota Stem Cell Institute (SCI) have demonstrated, for the first time, the ability of adult bone marrow stem cells to differentiate in vitro as hepatocytes (liver cells) with hepatocyte phenotype and function.

MINNEAPOLIS / ST. PAUL -- Researchers at the University of Minnesota Stem Cell Institute (SCI) have demonstrated, for the first time, the ability of adult bone marrow stem cells to differentiate in vitro as hepatocytes (liver cells) with hepatocyte phenotype and function. The findings will be published in the May 15, 2002 issue of the Journal of Clinical Investigation. The paper can be found at http://www.jci.org.

"What we have seen is that adult stem cells cultured from the bone marrow of humans, mice and rats can be induced to differentiate into cells that look, stain and function like liver cells," said Catherine Verfaillie, M.D., director of the University of Minnesota Stem Cell Institute and author of the research. "Our lab shows, for the first time, clear indication that these stem cells function like liver cells in that they secreted three key elements: albumin, the most abundant protein made by the liver; urea, produced only by liver and kidney epithelium; and cytochrome P450, the major detoxifying enzyme in the liver."

According to Verfaillie, the benefits of the research could be broad.

"These adult stem cells are indeed a good source of cells for patients with genetic diseases of the liver, such as alpha 1 antitrypsin deficiency, which affects 100,000 in the United States," she said. "It may also be helpful for some types of cirrhosis or acute liver failure due to medications. In addition, the cells might be used to create bio-artificial livers and replace the use of pig liver cells, which are a commonly used source of cells now. Much as dialysis machines can be a bridge for patients waiting for kidneys, a bio-artificial liver can help bridge a person from acute liver failure to transplant.

"The immediate benefit might well be to help pharmaceutical researchers and manufacturers screen for toxicity and efficiency of drugs prior to phase I clinical trials."

Verfaillie and her colleagues announced late last year that these cells, called multipotent adult progenitor cells (MAPCs), demonstrate the potential to differentiate beyond mesenchymal cells, into cells of visceral mesodermal origin, such as endothelium, as well as into cells with neuroectodermal phenotype and function.

The objective of the Stem Cell Institute is to further our understanding of the potential of stem cells to improve human and animal health. The SCI is a part of the University of Minnesota's Academic Health Center and is an interdisciplinary center with member faculty representing a diverse group of university schools, colleges and centers. For online information about the Stem Cell Institute, go to http://www1.umn.edu/stemcell.


Story Source:

The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota. "Adult Bone Marrow Stem Cells Can Become Liver Cells, Minnesota Researchers Report." ScienceDaily. ScienceDaily, 15 May 2002. <www.sciencedaily.com/releases/2002/05/020515074318.htm>.
University Of Minnesota. (2002, May 15). Adult Bone Marrow Stem Cells Can Become Liver Cells, Minnesota Researchers Report. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2002/05/020515074318.htm
University Of Minnesota. "Adult Bone Marrow Stem Cells Can Become Liver Cells, Minnesota Researchers Report." ScienceDaily. www.sciencedaily.com/releases/2002/05/020515074318.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins