Featured Research

from universities, journals, and other organizations

Mayo Clinic Researchers Discover Enzyme Has Potential To Stop Multiple Sclerosis Tissue Damage

Date:
May 24, 2002
Source:
Mayo Clinic
Summary:
Mayo Clinic researchers have found a new clue in the search for a way to stop the tissue damage, or demyelination, that occurs in multiple sclerosis (MS) or related central nervous system diseases. They found a dramatic increase in a newly discovered degradative enzyme, myelencephalon-specific protease (MSP), in demyelinated tissue, indicating that inhibiting this enzyme could potentially block the process of tissue damage.

ROCHESTER, MINN. -- Mayo Clinic researchers have found a new clue in the search for a way to stop the tissue damage, or demyelination, that occurs in multiple sclerosis (MS) or related central nervous system diseases. They found a dramatic increase in a newly discovered degradative enzyme, myelencephalon-specific protease (MSP), in demyelinated tissue, indicating that inhibiting this enzyme could potentially block the process of tissue damage.

Related Articles


This is a first-ever finding of the link between MSP and the debilitation that patients experience in MS.

This study will be published in the June 2002 issue of Brain, published by Oxford University Press, http://brain.oupjournals.org/.

"If you could control this enzyme, you could possibly decrease the development of disease," said Isobel Scarisbrick, Ph.D., Mayo Clinic neuroscientist and lead author of this study. "Excess MSP, as is present in inflammatory central nervous system lesions such as those in MS, may promote demyelination."

Dr. Scarisbrick and colleagues discovered MSP in 1997 while she was a research fellow at Mayo Clinic in Jacksonville, Fla. They cloned MSP and developed probes and other tools to work with the enzyme and attempt to determine its role in demyelination.

In the researchers' investigation of mouse and human MS tissue, they discovered MSP's dramatic increase in inflammatory cells in actively demyelinating human MS lesions. MSP is a multifunctional enzyme, facilitating entry of inflammatory cells into the brain and also contributing to tissue destruction when overexpressed. It also may harm processes of the oligodendroglia, cells found in the central nervous system that form the myelin sheath protecting the axon, a component of nerve cells. When functioning normally, however, MSP contributes to proper oligodendroglia function.

In the MS field, researchers have made many strides in learning about the genetics, origin and development of the disease, but no treatment has yet been found to be effective in treating all MS cases. Dr. Scarisbrick and colleagues view their new findings cautiously and not as a panacea, but yet are hopeful about the possibilities for future treatment development.

"We're not reporting this as a cure, but it represents something that could be targeted for therapy," says Dr. Scarisbrick. "We have a lot more work to do." Her colleague, Moses Rodriguez, M.D., Mayo Clinic neurologist, concurs. "This is a very important enzyme," says Dr. Rodriguez. "It really has therapeutic potential."

This study was supported by a pilot study grant from the National Multiple Sclerosis Society.

MS is an inflammatory demyelinating central nervous system (CNS) disease. It occurs most commonly in those between the ages of 20 and 40, and it is the most frequent neurological disorder in young adults in North America and Europe. Approximately 330,000 people in the United States have MS. Though researchers are still investigating the precise causes of MS and related CNS diseases, it is thought to be an autoimmune disease resulting from a triggering of the body's own immune system to destroy the myelin sheath covering the nerve fibers.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Mayo Clinic Researchers Discover Enzyme Has Potential To Stop Multiple Sclerosis Tissue Damage." ScienceDaily. ScienceDaily, 24 May 2002. <www.sciencedaily.com/releases/2002/05/020524072313.htm>.
Mayo Clinic. (2002, May 24). Mayo Clinic Researchers Discover Enzyme Has Potential To Stop Multiple Sclerosis Tissue Damage. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2002/05/020524072313.htm
Mayo Clinic. "Mayo Clinic Researchers Discover Enzyme Has Potential To Stop Multiple Sclerosis Tissue Damage." ScienceDaily. www.sciencedaily.com/releases/2002/05/020524072313.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com
Doctors Often Give In To Vaccine-Wary Parents

Doctors Often Give In To Vaccine-Wary Parents

Newsy (Mar. 2, 2015) A new survey published in the journal Pediatrics found many doctors are giving in to parents&apos; requests to delay vaccinating their children. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins