Featured Research

from universities, journals, and other organizations

UCLA Scientists Image How Parkinson's Genes Misfire In Mice

Date:
May 30, 2002
Source:
University Of California - Los Angeles
Summary:
UCLA scientists have developed a fast new way to image how thousands of genes misfire proteins in a mouse model of Parkinson’s disease. The approach may provide a research blueprint for pinpointing the abnormal brain regions linked to autism and schizophrenia.

UCLA scientists have developed a fast new way to image how thousands of genes misfire proteins in a mouse model of Parkinson’s disease. The approach may provide a research blueprint for pinpointing the abnormal brain regions linked to autism and schizophrenia.

The new findings are reported in the June edition of Genome Research.

Last year, UCLA pharmacologist Desmond Smith developed a new method to rapidly track how genes express proteins in the human brain. Called “voxelation,” the approach involves cutting the brain into cubes, then using DNA chip technology and math to reconstruct gene expression patterns in three-dimensional images.

This time, Smith used voxelation to compare gene expression in the brains of mice. Half of the mice received drugs to induce Parkinson’s disease. The UCLA team analyzed the brain cubes with DNA chips to track the expression of 9,000 genes simultaneously. They then combined the 9,000 resulting images to visualize how the genes construct the brain.

When they compared the colored brain images of the healthy and diseased mice, Smith and his colleagues discovered that the brains of the mice with Parkinson’s disease showed an abnormal shift in gene activity. The patterns of gene expression had moved and were not located in the brain where they should have been.

“This approach identifies which genes play a role in abnormal brain function and where they are located,” said Smith, UCLA assistant professor of molecular and medical pharmacology. “We can use this information to narrow down the brain regions linked to genetic disorders and pinpoint the genes responsible for causing them.”

The UCLA study was funded by the National Institute of Drug Abuse, Staglin Music Festival, National Alliance for Research on Schizophrenia and Depression, National Science Foundation, National Foundation for Functional Brain Imaging, Dana Foundation, Merck Genome Research Institute and W.M. Keck Foundation.


Story Source:

The above story is based on materials provided by University Of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Los Angeles. "UCLA Scientists Image How Parkinson's Genes Misfire In Mice." ScienceDaily. ScienceDaily, 30 May 2002. <www.sciencedaily.com/releases/2002/05/020530072657.htm>.
University Of California - Los Angeles. (2002, May 30). UCLA Scientists Image How Parkinson's Genes Misfire In Mice. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2002/05/020530072657.htm
University Of California - Los Angeles. "UCLA Scientists Image How Parkinson's Genes Misfire In Mice." ScienceDaily. www.sciencedaily.com/releases/2002/05/020530072657.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins