Featured Research

from universities, journals, and other organizations

Genetic Fingerprint Of Lung Cancer Predicts Treatment Outcome

Date:
June 3, 2002
Source:
University Of Toronto
Summary:
New research from Toronto's Princess Margaret Hospital identifies the genetic fingerprint for lung cancer that may eventually help determine which patients are at high risk for cancer recurrence after surgery.

New research from Toronto's Princess Margaret Hospital identifies the genetic fingerprint for lung cancer that may eventually help determine which patients are at high risk for cancer recurrence after surgery.

The findings, published in this month's edition of the international scientific journal Cancer Research, come after scientists at Princess Margaret Hospital's research arm, Ontario Cancer Institute (OCI), examined over 19,000 genes in a group of 39 lung cancer patients. The scientists discovered unique genetic differences between lung cancer patients that had high likelihood of failing standard treatment compared to those with a better prognosis. Generally, about 50-60 per cent of lung cancer patients treated by surgery will have their cancer reoccur.

"This genetic fingerprint is actually a pattern of genes in the lung tumor that correlated with dramatically different chances of cancer relapse," said Dr. Ming Tsao, leader of the study, a pathologist with Princess Margaret Hospital and Professor of Laboratory Medicine and Pathobiology at the University of Toronto. "In the future, this may allow us to be much more precise in assessing risk and determining whether to be more aggressive in our treatment for some patients."

Dr. Dennis Wigle, lead author and Director of Cancer Genomics for the Lung Cancer site group at University Health Network, said: "This is an exciting finding, not just for the results, but also in the way we approached the research."

Rather than examining genes individually in hope of discovering a single one responsible for lung cancer, the researchers started with over 19,000 genes that were narrowed to the 3,000 which seemed most likely to be important. Using microarrays produced at the University Health Network's Clinical Genomics Centre and the latest computer software, the researchers further narrowed the search to a cluster of 22 genes. These genes were expressed differently in patients whose lung cancer reappeared after treatment compared to those whose cancer did not reoccur within two years.

The discovery is not based on a single abnormality in any particular gene, but rather the recognition that it is the pattern of many interconnected genes that appears to be controlled differently in lung cancer. This ability to measure the levels of thousands of genes all at once provides unprecedented insight into the inner workings of individual lung tumors.

"The goal is to further refine the fingerprint and eventually produce a lung cancer-specific microarray for testing in clinical trials," said Dr. Frances Shepherd, the Head of the Lung Cancer site group at University Health Network, and the Chair of the National Cancer Institute of Canada Clinical Trials Group Lung Cancer Committee.

The study was supported by grants from the National Cancer Institute of Canada, the National Science and Engineering research Council of Canada, the Physicians' Services Inc. Foundation and the Princess Margaret Hospital Microarray Clinical Research Program.

Lung cancer remains by the far the number one cancer killer. Last year alone, an estimated 18,000 Canadians died from lung cancer, while another 21,200 were diagnosed with the disease.

Princess Margaret Hospital and its research arm, Ontario Cancer Institute, have achieved an international reputation as global leaders in the fight against cancer. Princess Margaret Hospital is a member of the University Health Network, which also includes Toronto General Hospital and Toronto Western Hospital. All three are teaching hospitals affiliated with the University of Toronto.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Genetic Fingerprint Of Lung Cancer Predicts Treatment Outcome." ScienceDaily. ScienceDaily, 3 June 2002. <www.sciencedaily.com/releases/2002/06/020603071855.htm>.
University Of Toronto. (2002, June 3). Genetic Fingerprint Of Lung Cancer Predicts Treatment Outcome. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2002/06/020603071855.htm
University Of Toronto. "Genetic Fingerprint Of Lung Cancer Predicts Treatment Outcome." ScienceDaily. www.sciencedaily.com/releases/2002/06/020603071855.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins