Featured Research

from universities, journals, and other organizations

Elevated Levels Of Cholesterol Play An Even Greater Role In Development Of Alzheimer's, Study Shows

Date:
June 19, 2002
Source:
Georgetown University Medical Center
Summary:
Research at Georgetown University Medical Center has led to a deeper understanding of the role that elevated cholesterol plays in the development of Alzheimer's disease.

Research at Georgetown University Medical Center has led to a deeper understanding of the role that elevated cholesterol plays in the development of Alzheimer's disease.

APP, a protein found in several major organs including the brain and heart, is present in all people. Its normal function in the body is unknown, but in people with Alzheimer's, APP is abnormally processed and converted to beta amyloid protein. When fragments of this protein break off, they become entangled, leading to the plaques that are one of the characteristic structural abnormalities found in the brains of people suffering from Alzheimer's.

"Past research has shown that high cholesterol levels appear to increase APP levels, which in turn leads to increased levels of beta amyloid protein and the risk of accumulation of amyloid beta peptide," said Vassilios Papadopoulos, PhD, professor of cell biology and pharmacology. "Our research showed that high cholesterol levels also increase the rate at which the amyloid beta peptides break off and form the tangles that kill brain cells."

In addition to this discovery, the Georgetown research also found that high cholesterol increases the production of another protein, apolipoprotein E (APOE), which is mainly responsible for transportation of cholesterol out of the cell. Researchers discovered that too much APOE results in the accumulation of free cholesterol, which is toxic to human nerve cells.

Papadopoulos and colleagues found that introducing a certain type of protein, bovine lipoproteins, would bind with the free cholesterol, allowing it to be transported back to the liver and negating its harmful effects.

"By giving the dangerous free cholesterol something to bind to, we are paving the way for possible new therapies," Papadopoulos said. "Our study adds to the growing body of evidence implicating high cholesterol as a significant risk factor in Alzheimer's disease, and breaks new ground in showing the damage caused by excessive levels of cholesterol." Papadopoulos added that many years of further study are required before any therapy derived from his team's findings might be tested in humans.

Zhi-Xing Yao, PhD, assistant professor of cell biology, and Papadopoulos will present these findings at the 2002 annual meeting of The Endocrine Society, June 19-22 in San Francisco. Additionally, this work has been accepted for publication in The FASEB Journal, the journal of the Federation of American Societies for Experimental Biology.

Georgetown University Medical Center includes the School of Medicine, School of Nursing & Health Studies, and a $120 million biomedical research enterprise.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Elevated Levels Of Cholesterol Play An Even Greater Role In Development Of Alzheimer's, Study Shows." ScienceDaily. ScienceDaily, 19 June 2002. <www.sciencedaily.com/releases/2002/06/020619073645.htm>.
Georgetown University Medical Center. (2002, June 19). Elevated Levels Of Cholesterol Play An Even Greater Role In Development Of Alzheimer's, Study Shows. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2002/06/020619073645.htm
Georgetown University Medical Center. "Elevated Levels Of Cholesterol Play An Even Greater Role In Development Of Alzheimer's, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2002/06/020619073645.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins