Featured Research

from universities, journals, and other organizations

Growth Hormone May Stimulate Production Of T Cells To Boost Body's Ability To Fight HIV

Date:
July 12, 2002
Source:
University Of California - San Francisco
Summary:
Growth hormone may stimulate the production of T cells in HIV-infected patients, research at the Gladstone Institute of Virology and Immunology shows. T cells are the immune system cells that HIV attacks and destroys, leaving patients without defenses against the opportunistic infections of AIDS.

BARCELONA -- Growth hormone may stimulate the production of T cells in HIV-infected patients, research at the Gladstone Institute of Virology and Immunology shows. T cells are the immune system cells that HIV attacks and destroys, leaving patients without defenses against the opportunistic infections of AIDS.

Laura Napolitano, MD, lead investigator of the study, presented the research on July 11 at the 14th International AIDS Conference here in Barcelona. Napolitano is a staff research investigator at Gladstone and UCSF assistant professor of medicine.

"Finding a way to stimulate the thymus to produce T cells would help HIV-infected patients to preserve and restore their embattled immune systems," Napolitano said. This study is the first to show that human thymic function can be significantly enhanced by growth hormone therapy to produce new T cells.

Results of the study were published in the May issue of the journal AIDS.

In the study, the researchers gave five HIV-infected male patients daily doses of growth hormone. After six months, the size of the thymus and the number of new T cells circulating in the blood increased significantly.

"The degree of change in the thymus was remarkable," Napolitano said. "Over the past five years, we have studied thymic function in more than four dozen similar patients who did not receive growth hormone, and we have never seen such striking changes in the thymus."

However, growth hormone therapy is not yet ready to be prescribed to stimulate immune function in HIV-infected patients. The study was small, and two of the five patients in the study experienced adverse effects of growth hormone therapy. Potential side effects include the development of diabetes, bone pain, swelling of the arms and legs, abnormal bone growth and carpal tunnel syndrome.

Additionally, this preliminary study was limited in its scope and was not designed to examine whether growth hormone actually improved the health status of the patients.

"The results of the current study are preliminary, but give us hope that we may be able to provide therapies to stimulate thymic function and T-cell production in individuals infected with HIV," concluded Napolitano.

"Additional studies need to be completed before we can conclude that growth hormone therapy provides benefit to the immune system of HIV-infected patients," Napolitano said. "We need to establish that the benefits of therapy outweigh the risks."

To address these concerns, Napolitano, along with principal investigator Joseph "Mike" McCune, are now enrolling a larger study that will directly compare HIV-infected patients on and off growth hormone for a longer period of time and with a larger number of tests. McCune is a senior investigator at Gladstone and UCSF professor of medicine.

The Gladstone Institute of Virology and Immunology is one of three research institutes that comprise The J. David Gladstone Institutes, a private nonprofit biomedical research institution affiliated with UCSF. The institute is named for a prominent real estate developer who died in 1971. His will created a testamentary trust that reflects his long-standing personal interest in medical education and research.


Story Source:

The above story is based on materials provided by University Of California - San Francisco. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - San Francisco. "Growth Hormone May Stimulate Production Of T Cells To Boost Body's Ability To Fight HIV." ScienceDaily. ScienceDaily, 12 July 2002. <www.sciencedaily.com/releases/2002/07/020712073931.htm>.
University Of California - San Francisco. (2002, July 12). Growth Hormone May Stimulate Production Of T Cells To Boost Body's Ability To Fight HIV. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2002/07/020712073931.htm
University Of California - San Francisco. "Growth Hormone May Stimulate Production Of T Cells To Boost Body's Ability To Fight HIV." ScienceDaily. www.sciencedaily.com/releases/2002/07/020712073931.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins