Featured Research

from universities, journals, and other organizations

Protein Transforms Sedentary Muscles Into Exercised Muscles, Researchers Report

Date:
August 15, 2002
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
Researchers have discovered a second protein found in skeletal muscle that can transform sedentary muscles into energy-producing, exercised muscles.

DALLAS – Aug. 15, 2002 – Researchers have discovered a second protein found in skeletal muscle that can transform sedentary muscles into energy-producing, exercised muscles.

Researchers from UT Southwestern Medical Center at Dallas and Harvard Medical School reported in a study in today's issue of Nature that when the protein PGC-1Q is genetically introduced in mice, easily fatigued type II muscle fibers are transformed into fatigue-resistant, mitochondria-rich, or energy-producing, type I muscle fibers that mimic highly exercised muscles.

"When you exercise, your muscles change fiber type specificity, switching from type II fibers to type I fibers," said Dr. Rhonda Bassel-Duby, associate professor of internal medicine at UT Southwestern and a co-author of the study. "When we expressed this protein in the mouse model, we found that the muscle switched from a type II muscle to a type I muscle. It visibly looked like a type I muscle. The presence of this protein alone switched the muscle type."

The protein PGC-1Q, identified by a Harvard Medical School researcher, activates energy production and oxidative metabolism. PGC-1Q is the second protein identified this year that's involved in muscle fiber-type switching. In an April study, reported in Science, UT Southwestern scientists reported that a protein called calcium/calmodulin-dependent protein kinase (CaMK) transformed type II muscle fibers into type I muscle fibers.

"The significance of this finding is that a nuclear cofactor alone was found to be sufficient to drive easily fatigued muscles into fatigue-resistant muscles," said Dr. Hai Wu, second author of the study and a postdoctoral researcher in molecular biology at UT Southwestern.

UT Southwestern researchers performed fatigue resistance measurements in the mice by stimulating the muscles and evaluating the response. The muscles were subjected to continuous electrical stimulation, which mimics muscle contraction during exercise.

"After evaluating the measurements we found that the muscles looked like and functioned as a type I muscle," Bassel-Duby said.

UT Southwestern scientists also performed the muscle-fiber type analysis for today's study and are continuing their own research into the signal transduction pathways that are involved in muscle fiber-type switching.

"The long-term goal of this research is to provide insight and treatment therapy to patients who have muscle fatigue, or are confined to bed rest, to enable them to have stronger, exercised muscles," Bassel-Duby said.

Other UT Southwestern researchers involved in the Nature study were Dr. Eric Olson, chairman of molecular biology, and Dr. Eiji Isotani, a former visiting assistant professor in physiology.

The study was funded by grants from the National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "Protein Transforms Sedentary Muscles Into Exercised Muscles, Researchers Report." ScienceDaily. ScienceDaily, 15 August 2002. <www.sciencedaily.com/releases/2002/08/020815072837.htm>.
University Of Texas Southwestern Medical Center At Dallas. (2002, August 15). Protein Transforms Sedentary Muscles Into Exercised Muscles, Researchers Report. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2002/08/020815072837.htm
University Of Texas Southwestern Medical Center At Dallas. "Protein Transforms Sedentary Muscles Into Exercised Muscles, Researchers Report." ScienceDaily. www.sciencedaily.com/releases/2002/08/020815072837.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins