Featured Research

from universities, journals, and other organizations

Cell Transplants Look Promising For Stroke Recovery

Date:
September 2, 2002
Source:
American Academy Of Neurology
Summary:
Using transplants of bone marrow cells improved the recovery from stroke in rat experiments, according to a study published in the August 27 issue of Neurology, the scientific journal of the American Academy of Neurology.

St. Paul, MN – Using transplants of bone marrow cells improved the recovery from stroke in rat experiments, according to a study published in the August 27 issue of Neurology, the scientific journal of the American Academy of Neurology. The rats treated with an intravenous transplant of adult human stromal cells (mature cells from bone marrow) had significant improvements in their ability to function 14 days after the stroke, compared to rats that did not receive transplants after a stroke.

"These are smart cells that selectively migrate to the site of injury and become little factories producing an array of helpful molecules to repair the tissue," said study author Michael Chopp, PhD, of Henry Ford Hospital in Detroit, Mich., and Oakland University in Rochester, Mich. "We believe this therapy shows promise in treating stroke, Parkinson's disease, spinal cord injury and traumatic brain injury."

For the study, bone marrow cells were taken from three healthy human donors. Strokes were then induced in the rats and they were given the cells intravenously one day after the stroke. Other groups treated with fibroblast cells or not treated served as controls.

The rats were tested on their motor and sensory abilities and on their reflexes before the stroke and at one day, seven days and 14 days after the stroke. In a test of sensory abilities 14 days after the stroke, the rats treated with marrow stromal cells completed the test 60 percent faster than the non-treated rats. A detailed neurological examination showed that 14 days after the stroke the treated rats had a 30-percent improvement in overall neurological score compared to the control rats.

Compared to the control rats, the rats receiving marrow stromal cells produced more neurotrophic factors and nerve growth factors that stimulate cells to grow. They also had less cell death in the area of the stroke than the control rats. Chopp said the next step is to test the procedure in small numbers of humans to make sure it is safe. Marrow stromal cells have been used in human cancer patients.

The treatment is exciting in part because it appears to give doctors a longer time window to treat stroke patients than current treatments, according to neurologist and stroke recovery researcher Thomas A. Kent, MD, of the University of Texas Medical Branch in Galveston, Texas, who wrote an editorial accompanying the article.

"It's very difficult to treat people with a stroke within a narrow time window," he said. "Many people still don't recognize the symptoms of stroke and get to an emergency room quickly enough for treatment. If this new treatment is effective, it could expand the treatment window by several hours or even longer."

Kent cautioned, however, that more studies are needed to determine the long-term effects of the transplants.

The study was supported by a grant from the National Institute of Neurological Disorders and Stroke.

The American Academy of Neurology, an association of more than 18,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. For more information about the American Academy of Neurology, visit its web site at http://www.aan.com.


Story Source:

The above story is based on materials provided by American Academy Of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy Of Neurology. "Cell Transplants Look Promising For Stroke Recovery." ScienceDaily. ScienceDaily, 2 September 2002. <www.sciencedaily.com/releases/2002/08/020828063512.htm>.
American Academy Of Neurology. (2002, September 2). Cell Transplants Look Promising For Stroke Recovery. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2002/08/020828063512.htm
American Academy Of Neurology. "Cell Transplants Look Promising For Stroke Recovery." ScienceDaily. www.sciencedaily.com/releases/2002/08/020828063512.htm (accessed October 21, 2014).

Share This



More Mind & Brain News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Your Birth Season Might Determine Your Temperament

Your Birth Season Might Determine Your Temperament

Newsy (Oct. 20, 2014) A new study says the season you're born in can determine your temperament — and one season has a surprising outcome. Video provided by Newsy
Powered by NewsLook.com
Court Ruling Means Kids' Online Activity Could Be On Parents

Court Ruling Means Kids' Online Activity Could Be On Parents

Newsy (Oct. 17, 2014) In a ruling attorneys for both sides agreed was a first of its kind, a Georgia appeals court said parents can be held liable for what kids put online. Video provided by Newsy
Powered by NewsLook.com
The Best Foods To Boost Your Mood

The Best Foods To Boost Your Mood

Buzz60 (Oct. 17, 2014) Feeling down? Reach for the refrigerator, not the medicine cabinet! TC Newman (@PurpleTCNewman) shares some of the best foods to boost your mood. Video provided by Buzz60
Powered by NewsLook.com
You Can Get Addicted To Google Glass, Apparently

You Can Get Addicted To Google Glass, Apparently

Newsy (Oct. 15, 2014) Researchers claim they’ve diagnosed the first example of the disorder in a 31-year-old U.S. Navy serviceman. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins