Evolution of a much-maligned yeast shows that drug resistance is a predictable outcome of exposure to drugs, say University of Toronto botanists. Microbes that survive drug treatment often become drug-resistant. Researchers in the labs of Professors Jim Anderson and Linda Kohn of botany have determined how this happens by studying the yeast Candida albicans and its genetic changes when exposed to drugs. "Ultimately, our findings could lead to the development of companion drugs that target these sets of genes, delaying or preventing the evolution of resistance to the therapeutic drug," says doctoral student Leah Cowen, the study's lead author.
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