Featured Research

from universities, journals, and other organizations

Yeast Research Targets Drug Resistance Battle

Date:
September 18, 2002
Source:
University Of Toronto
Summary:
Evolution of a much-maligned yeast shows that drug resistance is a predictable outcome of exposure to drugs, say University of Toronto botanists. Microbes that survive drug treatment often become drug-resistant. Researchers in the labs of Professors Jim Anderson and Linda Kohn of botany have determined how this happens by studying the yeast Candida albicans and its genetic changes when exposed to drugs.

Evolution of a much-maligned yeast shows that drug resistance is a predictable outcome of exposure to drugs, say University of Toronto botanists. Microbes that survive drug treatment often become drug-resistant. Researchers in the labs of Professors Jim Anderson and Linda Kohn of botany have determined how this happens by studying the yeast Candida albicans and its genetic changes when exposed to drugs. "Ultimately, our findings could lead to the development of companion drugs that target these sets of genes, delaying or preventing the evolution of resistance to the therapeutic drug," says doctoral student Leah Cowen, the study's lead author.

Related Articles


Researchers grew over 330 generations of the yeast - a common inhabitant of healthy humans that causes thrush, diaper rash and infections in women as well as life-threatening infections in immuno-compromised individuals - in the presence of the widely prescribed anti-fungal drug fluconazole. Drug resistance increased as the researchers had predicted. While they saw expected changes to the molecular pumps (which remove a variety of drugs from cells), they also noted changes in hundreds of genes. More surprisingly, they found the altered genes displayed three distinct patterns - a finding replicated in patient samples. Recognizing these patterns will make it easier for scientists to target drug therapy, Cowen says.

Funding for the research, published in Proceedings of the National Academy of Sciences, was provided by the Natural Sciences and Engineering Research Council of Canada. The drug fluconazole was supplied by Pfizer Inc.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Yeast Research Targets Drug Resistance Battle." ScienceDaily. ScienceDaily, 18 September 2002. <www.sciencedaily.com/releases/2002/09/020918064224.htm>.
University Of Toronto. (2002, September 18). Yeast Research Targets Drug Resistance Battle. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2002/09/020918064224.htm
University Of Toronto. "Yeast Research Targets Drug Resistance Battle." ScienceDaily. www.sciencedaily.com/releases/2002/09/020918064224.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins