Featured Research

from universities, journals, and other organizations

Yeast Research Targets Drug Resistance Battle

Date:
September 18, 2002
Source:
University Of Toronto
Summary:
Evolution of a much-maligned yeast shows that drug resistance is a predictable outcome of exposure to drugs, say University of Toronto botanists. Microbes that survive drug treatment often become drug-resistant. Researchers in the labs of Professors Jim Anderson and Linda Kohn of botany have determined how this happens by studying the yeast Candida albicans and its genetic changes when exposed to drugs.

Evolution of a much-maligned yeast shows that drug resistance is a predictable outcome of exposure to drugs, say University of Toronto botanists. Microbes that survive drug treatment often become drug-resistant. Researchers in the labs of Professors Jim Anderson and Linda Kohn of botany have determined how this happens by studying the yeast Candida albicans and its genetic changes when exposed to drugs. "Ultimately, our findings could lead to the development of companion drugs that target these sets of genes, delaying or preventing the evolution of resistance to the therapeutic drug," says doctoral student Leah Cowen, the study's lead author.

Researchers grew over 330 generations of the yeast - a common inhabitant of healthy humans that causes thrush, diaper rash and infections in women as well as life-threatening infections in immuno-compromised individuals - in the presence of the widely prescribed anti-fungal drug fluconazole. Drug resistance increased as the researchers had predicted. While they saw expected changes to the molecular pumps (which remove a variety of drugs from cells), they also noted changes in hundreds of genes. More surprisingly, they found the altered genes displayed three distinct patterns - a finding replicated in patient samples. Recognizing these patterns will make it easier for scientists to target drug therapy, Cowen says.

Funding for the research, published in Proceedings of the National Academy of Sciences, was provided by the Natural Sciences and Engineering Research Council of Canada. The drug fluconazole was supplied by Pfizer Inc.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Yeast Research Targets Drug Resistance Battle." ScienceDaily. ScienceDaily, 18 September 2002. <www.sciencedaily.com/releases/2002/09/020918064224.htm>.
University Of Toronto. (2002, September 18). Yeast Research Targets Drug Resistance Battle. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2002/09/020918064224.htm
University Of Toronto. "Yeast Research Targets Drug Resistance Battle." ScienceDaily. www.sciencedaily.com/releases/2002/09/020918064224.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins