Featured Research

from universities, journals, and other organizations

Cipro, Related Antibiotics Over-Prescribed, Fueling Microbe Resistance

Date:
October 1, 2002
Source:
University Of California - San Francisco
Summary:
A new study heightens concerns that Cipro and related broad-spectrum antibiotics known as fluoroquinolones are being over-prescribed, accelerating bacterial resistance to the drugs and reducing their ability to treat infections.

A new study heightens concerns that Cipro and related broad-spectrum antibiotics known as fluoroquinolones are being over-prescribed, accelerating bacterial resistance to the drugs and reducing their ability to treat infections.

Related Articles


The UCSF-led study evaluated the records of more than 13,000 patients across the country hospitalized for "community-acquired" pneumonia – pneumonia that developed before the patient was hospitalized. The researchers found that fluoroquinolones were widely prescribed to patients discharged from the hospital, even when tests showed that narrow-spectrum antibiotics were appropriate.

"Overuse of fluoroquinolones for infections that can be treated with narrow-spectrum antibiotics has seriously eroded their effectiveness," said Joseph Guglielmo, PharmD, UCSF professor of clinical pharmacy and director of the antimicrobial review program at the UCSF Medical Center.

Fluoroquinolones have been particularly useful in treating common bladder infections and infections associated with cystic fibrosis. "But we've seen dramatic increases in bacterial resistance to these agents over the past few years," Guglielmo said.

He presented the new findings in a poster session at the annual meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in San Diego.

The study found that 30 to 35 percent of patients with bacterial pneumonia due to penicillin-susceptible streptococcus were prescribed the broad-spectrum fluorquinolones upon discharge from the hospital. The American Thoracic Society recommends that the narrowest spectrum agent be chosen. Prescribing the broader-spectrum drug accelerates development of bacterial resistance to the antibiotics, Guglielmo said.

The E. coli bacterium is the most common cause of bladder infections, and Cipro and related fluoroquinolones are the most widely used and recommended antibiotic to treat these infections, Guglielmo said. As recently as 1997 the drugs were 97 percent active against E. coli. Now, susceptibility of this organism to fluororquinolones has dropped to 79 percent at UCSF, he said.

The situation is more alarming in relation to cystic fibrosis. Lung infections in people with cystic fibrosis traditionally have been treatable with fluoroquinolones. Cipro and related drugs are the only antibiotics patients can take orally to combat Pseudomonas aeurginosa, the most common bacterium associated with cystic fibrosis, Guglielmo said. Pills offer important quality- of- life benefits to patients who would otherwise need intravenous antibiotics.

However, in just 10 years Pseudomonas aeurginosa has become dramatically more resistant to these drugs. The drugs were 95 percent effective in 1992, and now that effectiveness has dropped to about 62 percent.

###The study was performed as part of the Centers for Medicare and Medicaid National Pneumonia Project and is based upon the national Medicare database.

Collaborating on the study with Guglielmo were Nancy N. Chang, PharmD, UCSF assistant clinical professor of clinical pharmacy; Dale W. Bratzler, DO; Lori Moore, RN; Claudette Shook and Cynthia K. Murray, PhD, at the Health Care Quality Improvement Program, Oklahoma Foundation for Medical Quality; and Peter M Houck, MD, at the Centers for Medicare and Medicaid Services, Seattle.


Story Source:

The above story is based on materials provided by University Of California - San Francisco. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - San Francisco. "Cipro, Related Antibiotics Over-Prescribed, Fueling Microbe Resistance." ScienceDaily. ScienceDaily, 1 October 2002. <www.sciencedaily.com/releases/2002/10/021001040627.htm>.
University Of California - San Francisco. (2002, October 1). Cipro, Related Antibiotics Over-Prescribed, Fueling Microbe Resistance. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2002/10/021001040627.htm
University Of California - San Francisco. "Cipro, Related Antibiotics Over-Prescribed, Fueling Microbe Resistance." ScienceDaily. www.sciencedaily.com/releases/2002/10/021001040627.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins