Featured Research

from universities, journals, and other organizations

Colorado State University Biochemists Identify Saturated Fat Byproduct As Likely Contributor To Type 2 Diabetes

Date:
January 27, 2003
Source:
Colorado State University
Summary:
Innovative research from Colorado State University biochemists has identified a saturated fat byproduct as a potential contributor to the development of type 2 diabetes. The breakthrough has the potential to lead to novel treatments for diabetics and is aimed at reducing or eliminating the effects of a disease that affects about 16 million Americans.

FORT COLLINS -- Innovative research from Colorado State University biochemists has identified a saturated fat byproduct as a potential contributor to the development of type 2 diabetes. The breakthrough has the potential to lead to novel treatments for diabetics and is aimed at reducing or eliminating the effects of a disease that affects about 16 million Americans.

Research results posted on the Journal of Biological Chemistry's Web site at www.jbc.org show that a saturated fat metabolite called ceramide contributes to the development of insulin resistance in cultured cell experiments. Furthermore, the lab studies indicate that excess accumulation of ceramide in the body is a necessary link connecting saturated fats to insulin resistance. The entire research paper can be found on the Web site's papers in press section and is expected to be published in the journal's April print edition.

"Our research team is making great progress -- we have determined that ceramide is undeniably an important factor in the development of insulin resistance in muscle tissue," said Scott Summers, assistant professor in the Department of Biochemistry and Molecular Biology and principal investigator of the study. "These findings suggest that medication aimed to prevent ceramide accumulation in body tissue might lessen or even prevent insulin resistance and lead to breakthroughs in the treatment of type 2 diabetes."

Summers added that the next step for the Colorado State research team is to determine if they can produce the same results in more complicated models of insulin resistance, such as diabetic rodents. "If the same role for ceramide is proven in rodent models, we can then begin developing medications or forms of gene therapy to prevent ceramide accumulation in tissue cells and potentially eliminate the need for many diabetics to take insulin," he said.

Type 2 diabetes results from either a decreased discharge of insulin into the bloodstream or an inability of the released insulin to induce the necessary nutrient storage in body tissues. Summers' research focuses on the latter, where body cells essentially ignore insulin. As a result of insulin resistance, skeletal muscle and other tissues cannot absorb glucose appropriately, and blood glucose levels remain elevated in a state of hyperglycemia. If uncontrolled, this leads to a wasting of body tissues and death. Complications of prolonged hyperglycemia also include diseases of the eye, kidney and cardiovascular system.

Summers' research has been funded by grants from the American Diabetes Association, the National Institutes of Health, the American Heart Association and the March of Dimes. The research is of particular interest because more than 80 percent of type 2 diabetics are obese, but the precise link between increased body fat and the development of diabetes has remained a mystery. Previous studies indicate that the excessive intake of saturated fats could contribute to the development of type 2 diabetes. However, the Colorado State research is the first to show that a specific saturated fatty acid metabolite is responsible for insulin resistance.

"We speculated that saturated fats were not themselves responsible for antagonizing insulin action, but rather that some metabolite of the fats might be responsible for blocking insulin effects," said Jose Antonio Chavez, doctoral candidate on Summers' research team and lead author of the paper. "In lab studies, we incubated muscle tissue with saturated fats and used drugs to block the conversion of the fats into ceramide. This process completely prevented insulin resistance."

Chavez added that although abnormal ceramide accumulation is unlikely to account entirely for the diverse array of defects found in insulin-resistant tissues, the team's findings connect ceramide as a vital factor explaining some of the harmful effects that saturated fats have on the human body.

Diabetes accounts for about 15 percent of all health-care expenditures and totals more than $45 billion in direct medical costs each year in the United States. Type 2 diabetes is the most common form of the disease, 90 percent to 95 percent of all diabetics. Although children with the disease typically have type 1 diabetes, the rate of type 2 is rapidly rising among young people.

Insulin is a hormone in the body that stimulates the absorption and storage of carbohydrates and other nutrients in muscle and fat tissue. Following a meal, cells in the pancreas secrete insulin into the bloodstream which promotes the absorption and storage of carbohydrates and other nutrients in tissue while simultaneously suppressing glucose production by the liver. The inability of insulin to work effectively in peripheral tissues, mainly muscle, is termed insulin resistance.


Story Source:

The above story is based on materials provided by Colorado State University. Note: Materials may be edited for content and length.


Cite This Page:

Colorado State University. "Colorado State University Biochemists Identify Saturated Fat Byproduct As Likely Contributor To Type 2 Diabetes." ScienceDaily. ScienceDaily, 27 January 2003. <www.sciencedaily.com/releases/2003/01/030127080438.htm>.
Colorado State University. (2003, January 27). Colorado State University Biochemists Identify Saturated Fat Byproduct As Likely Contributor To Type 2 Diabetes. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2003/01/030127080438.htm
Colorado State University. "Colorado State University Biochemists Identify Saturated Fat Byproduct As Likely Contributor To Type 2 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2003/01/030127080438.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins