Featured Research

from universities, journals, and other organizations

Cancer Vaccine One Step Closer

Date:
February 20, 2003
Source:
Netherlands Organization For Scientific Research
Summary:
Andreea Ioan-Facsinay from Leiden University Medical Center has attached proteins from tumour cells to antibodies. With these she treated immune cells from a mouse. These treated cells were used to make a vaccine, which was shown to be effective in animal experiments. If the follow-up research is successful, vaccines against cancer will become available. However, that will take at least ten more years.

Andreea Ioan-Facsinay from Leiden University Medical Center has attached proteins from tumour cells to antibodies. With these she treated immune cells from a mouse. These treated cells were used to make a vaccine, which was shown to be effective in animal experiments. If the follow-up research is successful, vaccines against cancer will become available. However, that will take at least ten more years.

Vaccines against cancer are being sought on various fronts. That is not simple, as unlike the agents that cause most other diseases, cancer cells originate from within the body. Therefore, the immune system either does not recognise them or recognises them too late.

In principle, Ioan-Facsinay managed to solve this problem for some types of cancer. She successfully attached material from the tumour to antibodies. The immune cells from the mouse were then treated with this complex and injected back into the mouse. A vaccine was made from these re-injected cells, which induced an immune response against this cancer in animal experiments. Certain proteins in the surface of the immune cells, the so-called Fc receptors, are particularly important for the effectiveness of this vaccine.

The vaccine was also found to have a protective effect against cancer in new mice. Therefore, in principle, the vaccine can be used for prevention as well as treatment. For example, such a preventative use would be important for families with a high incidence of a certain form of cancer.

Fc receptors also play a role in arthritis and the immune response to the bacteria which cause whooping cough, as well as a possible role in allergies. These diseases can probably be treated or prevented by rendering these receptors invisible or by bombarding them with antibodies. However, further research is needed for this.

The researcher is optimistic about the possibilities of this research leading to the production of a vaccine against cancer, but she remains realistic about this. It will be at least two more years before experiments can be carried out on humans and then at least another eight years before there is a commercially available vaccine.

###

The research was funded by the Netherlands Organisation for Scientific Research (NWO).


Story Source:

The above story is based on materials provided by Netherlands Organization For Scientific Research. Note: Materials may be edited for content and length.


Cite This Page:

Netherlands Organization For Scientific Research. "Cancer Vaccine One Step Closer." ScienceDaily. ScienceDaily, 20 February 2003. <www.sciencedaily.com/releases/2003/02/030220082553.htm>.
Netherlands Organization For Scientific Research. (2003, February 20). Cancer Vaccine One Step Closer. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2003/02/030220082553.htm
Netherlands Organization For Scientific Research. "Cancer Vaccine One Step Closer." ScienceDaily. www.sciencedaily.com/releases/2003/02/030220082553.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins