Featured Research

from universities, journals, and other organizations

Common Industrial Chemical Now Linked To Male Infertility; Chemical Adversely Affects The Normal Development Of Sperm

Date:
March 7, 2003
Source:
Queen's University
Summary:
A chemical widely used in industry and present in ground water supplies, has now been found in the semen fluid of infertile men, reports a Queen's University research scientist.

(Kingston, ON) – A chemical widely used in industry and present in ground water supplies, has now been found in the semen fluid of infertile men, reports a Queen's University research scientist.

Dr. Poh-Gek Forkert's study of male mechanics who use trichloroethylene (TCE) in the workplace shows the presence of TCE in their seminal fluid. The team's findings are reported in the March issue of the international journal, Drug Metabolism and Disposition.

Also on the team were researchers from Wayne State University in Detroit, the University of Montreal, the Ottawa Health Research Institute, University of California at Davis, and the London Health Sciences Centre.

TCE is a volatile chemical used extensively in the automotive and metal industries as a de-greasing agent. It is also found in adhesives, lubricants, paints, varnishes, paint strippers, pesticides, spot removers and rug cleaning fluids, and has been detected in both underground and surface water sources.

Already linked to liver, kidney and lung damage, TCE has not until now been linked to reproductive disorders. The National Toxicology Program in the U.S. has estimated that 3.5 million workers are exposed to the chemical.

"Our earlier studies on mice showed damage to reproductive tissue following TCE exposure, and the findings suggested impaired fertility," says Dr. Forkert. "We were interested in determining if there is also a link between TCE exposure and infertility in humans."

In the most recent study, seminal fluid from mechanics who had been exposed to TCE in the workplace – and who had previously been diagnosed with infertility – was analyzed for TCE and its by-products (metabolites). All the semen samples contained TCE and metabolites.

"Taken together, the results of our studies in mice and in humans support the premise that TCE is metabolized in the human reproductive tract, and can adversely affect the normal development of sperm," says Dr. Forkert. "These results have serious implications for potential toxicities from chemicals that may lead to the reported decline in semen quality in humans."

The current occupational exposure limit for TCE is 50 ppm (parts per million). However, this regulation is often difficult to enforce, Dr. Forkert says.

The study was supported by the Toxic Substances Research Initiative, Health Canada, and Environment Canada.


Story Source:

The above story is based on materials provided by Queen's University. Note: Materials may be edited for content and length.


Cite This Page:

Queen's University. "Common Industrial Chemical Now Linked To Male Infertility; Chemical Adversely Affects The Normal Development Of Sperm." ScienceDaily. ScienceDaily, 7 March 2003. <www.sciencedaily.com/releases/2003/03/030307071845.htm>.
Queen's University. (2003, March 7). Common Industrial Chemical Now Linked To Male Infertility; Chemical Adversely Affects The Normal Development Of Sperm. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2003/03/030307071845.htm
Queen's University. "Common Industrial Chemical Now Linked To Male Infertility; Chemical Adversely Affects The Normal Development Of Sperm." ScienceDaily. www.sciencedaily.com/releases/2003/03/030307071845.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins