Featured Research

from universities, journals, and other organizations

A New Mechanism That Triggers Autoimmune Disease

Date:
May 2, 2003
Source:
University Of Virginia Health System
Summary:
In animal studies, researchers at the University of Virginia Health System have discovered a new mechanism that may trigger autoimmune disease in newborn babies. The research is published in the May issue of the Journal of Immunology.

CHARLOTTESVILLE, Va., May 1 – In animal studies, researchers at the University of Virginia Health System have discovered a new mechanism that may trigger autoimmune disease in newborn babies. The research is published in the May issue of the Journal of Immunology.

Related Articles


The researchers found that certain antibodies in female mice attached to an antigen in the cells of their babies. That process then stimulated a response by T-cells, which attacked the ovaries of the baby mice. Eighty to 90 percent of the baby mice had ovarian destruction or inflammation in the study, an indication of autoimmune disease.

Usually, T-cells help direct and control the immune response and are important in the destruction of invaders in the body such as viruses, bacteria and cancer. T-cells also are required for optimum production of antibodies. But under abnormal conditions, the same T-cells can turn on the body's own cells and cause autoimmune disease.

"The findings were unexpected," said Kenneth S. K. Tung, a professor of pathology and microbiology at U.Va. "This suggests that autoimmune disease, in addition to a genetic influence, also has an environmental and non-genetic influence. It is really a new paradigm, a new way of thinking about autoimmune disease."

Tung and his colleagues also found that there is a time window in which exposure to the mother's antibody is critical for development of autoimmune disease. Mice exposed to the maternal antibody did not develop autoimmune disease after the first five days of life. Tung believes that's because special cells that control the action of T cells weren't functioning in the early days of life.

Mice transfer antibodies to their offspring through milk. In humans, the transfer of antibodies from mother to baby happens through the placenta during pregnancy, Tung says.

Autoimmune disease occurs when the normal tolerance of the body to its own cells disappears and healthy cells are attacked. Diabetes mellitus, rheumatoid arthritis, lupus and multiple sclerosis are types of autoimmune disease.


Story Source:

The above story is based on materials provided by University Of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University Of Virginia Health System. "A New Mechanism That Triggers Autoimmune Disease." ScienceDaily. ScienceDaily, 2 May 2003. <www.sciencedaily.com/releases/2003/05/030502075341.htm>.
University Of Virginia Health System. (2003, May 2). A New Mechanism That Triggers Autoimmune Disease. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2003/05/030502075341.htm
University Of Virginia Health System. "A New Mechanism That Triggers Autoimmune Disease." ScienceDaily. www.sciencedaily.com/releases/2003/05/030502075341.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Humanoid Robot Can Recognise and Interact With People

Humanoid Robot Can Recognise and Interact With People

Reuters - Innovations Video Online (Apr. 20, 2015) An ultra-realistic humanoid robot called &apos;Han&apos; recognises and interprets people&apos;s facial expressions and can even hold simple conversations. Developers Hanson Robotics hope androids like Han could have uses in hospitality and health care industries where face-to-face communication is vital. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Labour Party Warns Britain's Health Service 'on Life Support'

Labour Party Warns Britain's Health Service 'on Life Support'

AFP (Apr. 20, 2015) Britain&apos;s opposition Labour Party Monday claimed the National Health Service (NHS) was &apos;on life support&apos; as it turned its attention to the state-run service, which is a key issue for the UK&apos;s May 7 general election. Video provided by AFP
Powered by NewsLook.com
Sierra Leone Students Back to School After Long Ebola Closure

Sierra Leone Students Back to School After Long Ebola Closure

Reuters - News Video Online (Apr. 20, 2015) After an eight-month break, children in Sierra Leone return to school for the first time since the beginning of the Ebola outbreak. Nathan Frandino reports. Video provided by Reuters
Powered by NewsLook.com
Teen E-Cigarette Use Triples, Government Debates Regulations

Teen E-Cigarette Use Triples, Government Debates Regulations

Newsy (Apr. 19, 2015) The Centers for Disease Control and Prevention says in 2014, 13.4 percent of high school students reported smoking an e-cigarette within 30 days. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins