Featured Research

from universities, journals, and other organizations

Researchers Discover Important Genetic Flaw In Family Affected By Schizophrenia

Date:
May 16, 2003
Source:
University Of Alberta
Summary:
Researchers at the University of Alberta have discovered a genetic flaw in a family suffering with schizophrenia that may help to explain an important biochemical process implicated in the onset of the disease.

Researchers at the University of Alberta have discovered a genetic flaw in a family suffering with schizophrenia that may help to explain an important biochemical process implicated in the onset of the disease.

Related Articles


Studying a British mother and daughter, the researchers discovered that both were found to have a "break" in a large gene on human chromosome 14, due to a rearranged chromosome.

The broken gene is a member of a family of similar genes affecting brain development and function. The genes in this group are involved in behaviour, memory and regulating day/night cycles.

"The fact that these genes--important in brain development and behaviour--are broken, cuts off important functions of the corresponding protein, particularly the ability to bind to DNA. Binding to DNA is an important way proteins can control the expression of other genes," says Professor Diane Cox, Chair of the Medical Genetics Department. "We believe this gene has all the features expected for a gene contributing to mental illness in this family."

Under the supervision of Dr. Cox, the work was conducted by PhD graduate student, Deepak Kamnasaran, and is published in the May issue of the Journal of Medical Genetics, entitled Disruption of the neuronal PAS3 gene in a family affected with schizophrenia.

Dr. Cox points out that schizophrenia is a complex disease and many genes are likely associated with its cause and development. "Our work isn't the whole story, but it helps us put in place a key piece of the puzzle that we can further explore."

The authors include: Dr. Kamnasaran (former University of Alberta graduate student, now a postdoctoral fellows at The Hospital for Sick Children, Toronto); Dr. Walter Muir (psychiatrist, Royal Edinburgh Hospital); Professor Malcolm Ferguson-Smith (Centre for Veterinary Science, Cambridge); and Dr. Cox (Medical Genetics, University of Alberta).

Funding for the work was provided by the March of Dimes (USA) and studentships to Dr. Kamnasaran from the Canadian Institutes of Health Research and the Alberta Heritage Foundation for Medical Research.

Schizophrenia is a biochemical brain disorder characterized by delusions, disordered thinking, hallucinations and a lack of motivation and energy. One in every 100 people in Canada is affected; it usually strikes between the ages of 15 and 25.

The U of A in Edmonton, Alberta is one of Canada's premier teaching and research universities serving more than 33,000 students with 6,000 faculty and staff. It continues to lead the country with the most 3M Teaching Fellows, Canada's only national award recognizing teaching excellence.


Story Source:

The above story is based on materials provided by University Of Alberta. Note: Materials may be edited for content and length.


Cite This Page:

University Of Alberta. "Researchers Discover Important Genetic Flaw In Family Affected By Schizophrenia." ScienceDaily. ScienceDaily, 16 May 2003. <www.sciencedaily.com/releases/2003/05/030516083103.htm>.
University Of Alberta. (2003, May 16). Researchers Discover Important Genetic Flaw In Family Affected By Schizophrenia. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2003/05/030516083103.htm
University Of Alberta. "Researchers Discover Important Genetic Flaw In Family Affected By Schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2003/05/030516083103.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins