Featured Research

from universities, journals, and other organizations

Camera Pill Reveals Damage From Anti-inflammatory Drugs

Date:
May 22, 2003
Source:
Baylor College Of Medicine
Summary:
Non-steroidal anti-inflammatory drugs (NSAIDs) may damage more of the intestine than previously thought, according to images taken by a swallowable, capsule-size camera pill used in a Baylor College of Medicine study.

HOUSTON (May 20, 2003)-- Non-steroidal anti-inflammatory drugs (NSAIDs) may damage more of the intestine than previously thought, according to images taken by a swallowable, capsule-size camera pill used in a Baylor College of Medicine study. According to the study, announced today at the Digestive Disease Week 2003 conference in Orlando, capsule endoscopy detected NSAIDs-related injury in the small bowel, an area of the gastrointestinal tract unreachable by other diagnostic tools such as endoscopes. The tool detected small bowel erosions in 62 percent of NSAID users compared to 5 percent of non-NSAID users.

Related Articles


"More than 100 million prescriptions for NSAIDS are written annually in the United States," said Dr. David Graham, lead author of the study and a professor of medicine and molecular virology at Baylor in Houston and chief of the gastroenterology section of Houston VA Medical Center. "The study shows that the patients who take NSAIDs regularly have an increased risk of small intestinal mucosal ulceration and bleeding."

NSAIDs are medications which reduce pain and inflammation over time. The drugs work by affecting chemicals in the body which cause inflammation, the prostaglandins. The same group of chemicals are also in the stomach, leading NSAIDs to cause indigestion, and possibly duodenal or stomach ulceration.

The capsule endoscope, developed by Given Imaging, allows medical professionals to view the entire small intestine. The system uses a disposable miniature video camera contained in a capsule, which the patient swallows. The capsule passes through the digestive tract, transmitting color images, without interfering with the patient's normal activities. Capsule endoscopy diagnoses a range of diseases of the small intestine including Crohn's Disease, Celiac disease, benign and malignant tumors of the small intestine, vascular disorders, medication related small bowel injury and pediatric small bowel disorders.

The study enrolled 40 patients, with a mean age of 49.5, who had arthritis including osteoarthritis, rheumatoid arthritis and gout. Twenty patients took NSAIDS daily for three months. Twenty patients took acetaminophen alone or nothing at all. All patients fasted overnight and underwent capsule endoscopy. The pylorus, the sphincter muscle that controls the lower opening of the stomach where it empties into the upper part of the small intestine, was marked on each video. Two investigators who were not told which therapy the participants received, reviewed each video beginning after the pylorus, where the small intestine starts.

Severe injury to the small bowel was seen in 23 percent of NSAID users compared to no severe injury in the controls. Severe damage was associated with high doses of indomethacin, naproxen, oxyprozocin and ibuprofen.

"This is a significant finding and suggests the need for periodic diagnostic monitoring with capsule endoscopy of patients who take NSAIDs regularly," Graham said.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Camera Pill Reveals Damage From Anti-inflammatory Drugs." ScienceDaily. ScienceDaily, 22 May 2003. <www.sciencedaily.com/releases/2003/05/030522083447.htm>.
Baylor College Of Medicine. (2003, May 22). Camera Pill Reveals Damage From Anti-inflammatory Drugs. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2003/05/030522083447.htm
Baylor College Of Medicine. "Camera Pill Reveals Damage From Anti-inflammatory Drugs." ScienceDaily. www.sciencedaily.com/releases/2003/05/030522083447.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins