Featured Research

from universities, journals, and other organizations

Sensory Cells For Hearing And Balance Are Fast-Developing, UVA Researchers Find

Date:
September 15, 2003
Source:
University Of Virginia Health System
Summary:
The functional development of hair cells in the inner ear that mediate hearing and balance takes place over a period of just one day in mouse embryos, according to a study by a research team at the University of Virginia Health System.

CHARLOTTESVILLE, Va., Sept. 14 – The functional development of hair cells in the inner ear that mediate hearing and balance takes place over a period of just one day in mouse embryos, according to a study by a research team at the University of Virginia Health System.

The U.Va. scientists found that three essential elements for development in the mouse inner ear appear between day 16 and day 17 of gestation, roughly equivalent to the late second trimester or early third trimester in the human fetus. The finding is important for ongoing research on regeneration of sensory hair cells in the human inner ear, say researchers, writing in the October edition of Nature Neuroscience, found online at www.nature.com/neuro.

"We were surprised that development of hair cells in the inner ear takes place so rapidly," said researcher Jeffrey R. Holt, an assistant professor of neuroscience and otolaryngology at U.Va. "Suddenly, the hair cells began working. To eventually discover how to regenerate hair cells in the human ear, we have to know when and how the original hair cells develop. That's why this research is so central to our knowledge."

The next challenge for scientists is to discover the molecular "switches" that turn on inner ear hair cells. "Scientists at U.Va. and elsewhere are working to test stem cells to see if they can develop into hair cells," Holt said. "If we can find the molecular process, we can potentially turn another cell type into an inner ear hair cell." The researchers said they are now assembling a list of processes these important cells go through to develop correctly. "We know the sequence," said study co-author Gw้na๋lle G้l้oc, an assistant professor of neuroscience and otolaryngology. "Now we can look at different cell types and see if they are on the right track to produce hair cells."

In the lab, Holt and G้l้oc found that hair cell transduction in mice, or the response to movement of hair bundles associated with hearing, begins to function over a 24 hours period, starting at embryonic day 16.

Interestingly, all three essential elements develop simultaneously: membrane-bound transduction channels, like trap doors, are formed to carry calcium and potassium which together create an electrical charge sending hearing and balance signals to the brain; microscopic tip-links are formed that operate under tension to open the trap door channel; finally, tiny adaptation motors are formed that regulate sensitivity and allow sounds that range from a faint whisper to a booming cannon to be heard.

The authors of the study said their work may mean a better understanding of congenital hearing and balance deficits in humans.


Story Source:

The above story is based on materials provided by University Of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University Of Virginia Health System. "Sensory Cells For Hearing And Balance Are Fast-Developing, UVA Researchers Find." ScienceDaily. ScienceDaily, 15 September 2003. <www.sciencedaily.com/releases/2003/09/030915072549.htm>.
University Of Virginia Health System. (2003, September 15). Sensory Cells For Hearing And Balance Are Fast-Developing, UVA Researchers Find. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2003/09/030915072549.htm
University Of Virginia Health System. "Sensory Cells For Hearing And Balance Are Fast-Developing, UVA Researchers Find." ScienceDaily. www.sciencedaily.com/releases/2003/09/030915072549.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) — The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) — Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins