Featured Research

from universities, journals, and other organizations

Does Stress-induced Impaired Pressure Natriuresis Contribute To Renal Disease?

Date:
September 30, 2003
Source:
American Physiological Society
Summary:
Previously published studies indicate that the renal pressure natriuresis mechanism -- the excretion of abnormal amounts of sodium in the urine -- is abnormal in all forms of hypertension studied thus far. A team of researchers has examined whether this mechanism, when affected by stress, contributes to the development of renal disease in adolescents.

(Atlanta, GA) – Maintaining a healthy balance of fluids and sodium in our body is important. An intricate part of the balance involves a control system known as the "renal-pressure natriuresis mechanism." Previously published studies indicate that the renal pressure natriuresis mechanism -- the excretion of abnormal amounts of sodium in the urine -- is abnormal in all forms of hypertension studied thus far. A team of researchers has examined whether this mechanism, when affected by stress, contributes to the development of renal disease in adolescents.

A New Study

The researchers are Coral Hanevold, Gregory Harshfield, Kathryn McLeod, Gaston Kapuku, Martha Wilson, Lynne Mackey, Delores Gillis and Lesley Edmunds, all of the Medical College of Georgia, Augusta, GA. They will present the results of their work, entitled, "Impaired Pressure Natriuresis and Renal Function in Adolescents" during the upcoming scientific conference, Understanding Renal and Cardiovascular Function Through Physiological Genomics, a meeting of the American Physiological Society (APS) (www.the-aps.org), being held October 1-4, 2003 at the Radisson Riverfront Hotel and Convention Center, Augusta, GA.

Methodology

The researchers examined changes in blood pressure (BP), urinary sodium excretion (UNaV), angiotensin II (Ang II) and urinary creatine (UCr) in 210 adolescents across a 5-hour test period. The period consisted of a 2-hour baseline, 1-hour stress period, and a 2-hour recovery period.

Blood pressure was obtained at 15-minute intervals and blood and urine samples were obtained hourly. The subjects were divided into those that increased (excreters: n=151) or decreased UNaV during stress (retainers: n=59). The groups were similar with respect to age, height, weight and casual BP.

Results

The researchers noted that:

the time by group interactions were significant for UNaV (P< 0.001) and UCr (P<0.03);

retainers continued to decrease UNv at 2 hours following stress;

UCr peaked during stress for both groups, but the change was greater for retainers (P<0.02), with a significantly higher level during stress (P< 0.006) that remained elevated until the last hour; and

the stress related increase in UCr was correlated with ANG II levels during stress (r=0.44:P<0.01). These patterns were coupled with higher levels of BP for retainers 2 hours following stress (113±10 versus 11±9 mmHg; P<0.05), despite similar levels prior to and during stress. Conclusions

The observed changes in UCr during and after stress, coupled with an extended period of relative hypertension post-stress, indicate that the workload of the kidney is excessive in subjects that show impaired stress-induced (i.e., retainers). These data indicate that this response pattern increases the load on the kidney, which may lead to the early development of renal disease.


Story Source:

The above story is based on materials provided by American Physiological Society. Note: Materials may be edited for content and length.


Cite This Page:

American Physiological Society. "Does Stress-induced Impaired Pressure Natriuresis Contribute To Renal Disease?." ScienceDaily. ScienceDaily, 30 September 2003. <www.sciencedaily.com/releases/2003/09/030930054652.htm>.
American Physiological Society. (2003, September 30). Does Stress-induced Impaired Pressure Natriuresis Contribute To Renal Disease?. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2003/09/030930054652.htm
American Physiological Society. "Does Stress-induced Impaired Pressure Natriuresis Contribute To Renal Disease?." ScienceDaily. www.sciencedaily.com/releases/2003/09/030930054652.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) — Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) — Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) — It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins