Featured Research

from universities, journals, and other organizations

Does Stress-induced Impaired Pressure Natriuresis Contribute To Renal Disease?

Date:
September 30, 2003
Source:
American Physiological Society
Summary:
Previously published studies indicate that the renal pressure natriuresis mechanism -- the excretion of abnormal amounts of sodium in the urine -- is abnormal in all forms of hypertension studied thus far. A team of researchers has examined whether this mechanism, when affected by stress, contributes to the development of renal disease in adolescents.

(Atlanta, GA) – Maintaining a healthy balance of fluids and sodium in our body is important. An intricate part of the balance involves a control system known as the "renal-pressure natriuresis mechanism." Previously published studies indicate that the renal pressure natriuresis mechanism -- the excretion of abnormal amounts of sodium in the urine -- is abnormal in all forms of hypertension studied thus far. A team of researchers has examined whether this mechanism, when affected by stress, contributes to the development of renal disease in adolescents.

A New Study

The researchers are Coral Hanevold, Gregory Harshfield, Kathryn McLeod, Gaston Kapuku, Martha Wilson, Lynne Mackey, Delores Gillis and Lesley Edmunds, all of the Medical College of Georgia, Augusta, GA. They will present the results of their work, entitled, "Impaired Pressure Natriuresis and Renal Function in Adolescents" during the upcoming scientific conference, Understanding Renal and Cardiovascular Function Through Physiological Genomics, a meeting of the American Physiological Society (APS) (www.the-aps.org), being held October 1-4, 2003 at the Radisson Riverfront Hotel and Convention Center, Augusta, GA.

Methodology

The researchers examined changes in blood pressure (BP), urinary sodium excretion (UNaV), angiotensin II (Ang II) and urinary creatine (UCr) in 210 adolescents across a 5-hour test period. The period consisted of a 2-hour baseline, 1-hour stress period, and a 2-hour recovery period.

Blood pressure was obtained at 15-minute intervals and blood and urine samples were obtained hourly. The subjects were divided into those that increased (excreters: n=151) or decreased UNaV during stress (retainers: n=59). The groups were similar with respect to age, height, weight and casual BP.

Results

The researchers noted that:

the time by group interactions were significant for UNaV (P< 0.001) and UCr (P<0.03);

retainers continued to decrease UNv at 2 hours following stress;

UCr peaked during stress for both groups, but the change was greater for retainers (P<0.02), with a significantly higher level during stress (P< 0.006) that remained elevated until the last hour; and

the stress related increase in UCr was correlated with ANG II levels during stress (r=0.44:P<0.01). These patterns were coupled with higher levels of BP for retainers 2 hours following stress (113ฑ10 versus 11ฑ9 mmHg; P<0.05), despite similar levels prior to and during stress. Conclusions

The observed changes in UCr during and after stress, coupled with an extended period of relative hypertension post-stress, indicate that the workload of the kidney is excessive in subjects that show impaired stress-induced (i.e., retainers). These data indicate that this response pattern increases the load on the kidney, which may lead to the early development of renal disease.


Story Source:

The above story is based on materials provided by American Physiological Society. Note: Materials may be edited for content and length.


Cite This Page:

American Physiological Society. "Does Stress-induced Impaired Pressure Natriuresis Contribute To Renal Disease?." ScienceDaily. ScienceDaily, 30 September 2003. <www.sciencedaily.com/releases/2003/09/030930054652.htm>.
American Physiological Society. (2003, September 30). Does Stress-induced Impaired Pressure Natriuresis Contribute To Renal Disease?. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2003/09/030930054652.htm
American Physiological Society. "Does Stress-induced Impaired Pressure Natriuresis Contribute To Renal Disease?." ScienceDaily. www.sciencedaily.com/releases/2003/09/030930054652.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins