Featured Research

from universities, journals, and other organizations

MIT Engineers Report New Approach To Tissue Engineering

Date:
October 14, 2003
Source:
Massachusetts Institute Of Technology
Summary:
MIT engineers report a new approach to creating three-dimensional samples of human tissue that could push researchers closer to their ultimate goal: tissues for therapeutic applications and replacement organs. The technique could also help answer questions in cell and developmental biology.

MIT engineers report a new approach to creating three-dimensional samples of human tissue that could push researchers closer to their ultimate goal: tissues for therapeutic applications and replacement organs. The technique could also help answer questions in cell and developmental biology.

Related Articles


The team "seeded" human embryonic stem cells, which have the potential to differentiate into a variety of specialized cells, onto a biodegradable polymer scaffold. By treating the scaffold/stem cell structure with chemical cues, or growth factors, known to stimulate the formation of specific cell types, the researchers coaxed the stem cells to form tissues with characteristics of developing human cartilage, liver, nerves and blood vessels.

"Here we show for the first time that polymer scaffolds … promoted proliferation, differentiation and organization of human embryonic stem cells into 3D structures," the researchers wrote in a paper to appear the week of Oct. 13 in the online edition of the Proceedings of the National Academy of Sciences.

Further, the resulting tissues continued to thrive when implanted in mice with suppressed immune systems (to eliminate rejection). They expressed human proteins, and integrated with the host's blood-vessel networks.

"For me it was very exciting to see that these [stem] cells could move around and start to 'talk' with one another, generating the different cell types common to a given tissue and organizing into that tissue," said Shulamit Levenberg, first author of the paper and a research associate in the Department of Chemical Engineering.

The technique could also have an impact on the study of cell and developmental biology. "When you give cells a three-dimensional structure [on which to grow], it's really a lot more like what's happening in the embryo," said Levenberg, a mother of four whose youngest child is seven months old.

Levenberg's colleagues on the work are Robert Langer, the Germeshausen Professor of Chemical and Biomedical Engineering; MIT alumna Ngan Huang (S.B. 2002); Erin Lavik, a postdoctoral fellow in the MIT-Harvard Division of Health Sciences and Technology who is now a professor at Yale; Arlin Rogers of MIT's Division of Comparative Medicine; and Joseph Itskovitz-Eldor of the Technion in Israel.

The work provides a new approach to prodding stem cells to grow into different tissues. Before, researchers created a variety of cell types from one batch of stem cells, then isolated the cell type of interest. The isolated cells were then grown on a given medium, such as a polymer scaffold. The same MIT team did just that last year with the endothelial cells that blood vessels are composed of.

This time around, the MIT researchers seeded stem cells directly into the scaffold. "We found that with different growth factors, we could push them in different directions," said Levenberg.

The polymer scaffold is key. "The scaffold provides physical cues for cell orientation and spreading, and pores provide space for remodeling of tissue structures," the researchers wrote.

The scaffold was carefully engineered. "If the scaffold is too soft," for example, "it collapses under the cells' mechanical forces," said Levenberg. The team also used two different polymers to create the scaffold. "One degrades quickly, the other more slowly," she said. "That gives cells room to grow while still retaining a support structure for them."

The work was supported by the National Institutes of Health. The human embryonic stem cells are from an NIH-approved line.


Story Source:

The above story is based on materials provided by Massachusetts Institute Of Technology. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts Institute Of Technology. "MIT Engineers Report New Approach To Tissue Engineering." ScienceDaily. ScienceDaily, 14 October 2003. <www.sciencedaily.com/releases/2003/10/031014072010.htm>.
Massachusetts Institute Of Technology. (2003, October 14). MIT Engineers Report New Approach To Tissue Engineering. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2003/10/031014072010.htm
Massachusetts Institute Of Technology. "MIT Engineers Report New Approach To Tissue Engineering." ScienceDaily. www.sciencedaily.com/releases/2003/10/031014072010.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins