Featured Research

from universities, journals, and other organizations

Universal Bone Marrow Cell Spurs Growth Of Vessels And Heart Muscle

Date:
November 11, 2003
Source:
American Heart Association
Summary:
A "universal stem cell clone" found in adult bone marrow regenerated blood vessels and heart muscle, according to research reported at the American Heart Association's Scientific Sessions 2003.

Orlando, Fla., Nov. 10 – A "universal stem cell clone" found in adult bone marrow regenerated blood vessels and heart muscle, according to research reported at the American Heart Association's Scientific Sessions 2003.

The cells, called human bone marrow-derived multipotent stem cells (hBMSC), were implanted into animal hearts where they formed multiple cell types.

The hBMSC improved animals' heart function, said the study's lead author, Young Sup Yoon, M.D., Ph.D., assistant professor of medicine at Tufts University School of Medicine in Boston.

"This study is exciting because it is the first to show that human bone marrow includes a clonal stem cell population that can differentiate into both vessels and heart muscle. These cells can regenerate the essential tissues of the heart," Yoon said. This finding comes from animal and laboratory research. Such stem cells might be used to regenerate damaged hearts for people who have acute and chronic heart failure. They also might help people with hypertension, diabetes or other blood vessel diseases.

The researchers found that these stem cells didn't belong to any previously known bone marrow-derived stem cell population (such as hematopoietic cells, the source for all types of blood cells or mesenchymal cells that give rise to cell types like bone and cartilage).

These adult bone marrow stem cells have been shown to differentiate into all three so-called "germ layers." The three germ layers of cells in early human development are the beginnings of the body's tissues and organs. Differentiation is the term that describes the process in which stem cells change into these specialized cells.

To find out if these unique stem cells would repair heart damage, the researchers induced a heart attack in rats and introduced the hBMSC into heart tissue around the affected area. They injected unselected bone marrow cells and saline as controls.

Heart function was measured by non-invasive echocardiography and by a pressure transducer, an instrument at the tip of a tiny catheter that is threaded through an artery into the heart to measure blood pressure and heart function.

Heart function after 28 days was better in rats that received the hBMSC than in the rats that received total bone marrow cells or saline.

The transplanted hBMSC differentiated into heart muscle cells and blood vessel cells.

Important proteins that encourage blood vessel growth, called angiogenic cytokines, also increased or were newly expressed. The same thing occurred with factors important to the development of the heart in utero, called cardiac transcription factors. The number of heart and vessel cells also increased after hBMSC transplantation.

Co-authors are Andrea Wecker, M.S.; Lindsay Heyd, B.S.; Jong Seon Park, M.D., Ph.D.; Allison Hanley, B.S. and Douglas W. Losordo, M.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Universal Bone Marrow Cell Spurs Growth Of Vessels And Heart Muscle." ScienceDaily. ScienceDaily, 11 November 2003. <www.sciencedaily.com/releases/2003/11/031111071905.htm>.
American Heart Association. (2003, November 11). Universal Bone Marrow Cell Spurs Growth Of Vessels And Heart Muscle. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2003/11/031111071905.htm
American Heart Association. "Universal Bone Marrow Cell Spurs Growth Of Vessels And Heart Muscle." ScienceDaily. www.sciencedaily.com/releases/2003/11/031111071905.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins