Featured Research

from universities, journals, and other organizations

Researchers Pinpoint Enzyme Involved In Arthritis Onset

Date:
November 13, 2003
Source:
BioMed Central
Summary:
Researchers from Cardiff University have uncovered a molecular pathway that plays a pivotal role in the onset of arthritis. Their research, published this week in Arthritis Research & Therapy, could aid in the discovery of novel targets for arthritis drugs.

Researchers from Cardiff University have uncovered a molecular pathway that plays a pivotal role in the onset of arthritis. Their research, published this week in Arthritis Research & Therapy, could aid in the discovery of novel targets for arthritis drugs.

Related Articles


The researchers found that inhibiting the enzyme PKR could prevent two processes central to the onset of arthritis: the production and activation of enzymes that break down connective tissue; and the release from cartilage of one of its principal constituents, proteoglycan.

They said: "Collectively these results support our hypothesis that PKR is implicated in the cartilage degradation that occurs in arthritic disease."

Despite the differences between osteoarthritis and rheumatoid arthritis, it is likely that similar molecular pathways can cause the degradation of cartilage in both diseases. Cartilage degradation results from an imbalance of enzymes that break down connective tissue and their inhibitors. In particular, activity levels of the enzymes MMP-2 and MMP-9 are frequently increased in the cartilage of people suffering from osteoarthritis.

The research team, led by Dr Sophie Gilbert, cultured cartilage cells in vitro. They then stimulated the cells with two molecules, TNF-a and C2-ceramide. The molecules simulated arthritic processes, increasing the release of proteoglycan and the production and activation of MMPs.

The researchers then repeated the experiment, but inhibited PKR at the same time. This time they found that there was no increase in the activation of MMP-2 or MMP–9 and that the release of proteoglycan was significantly reduced.

Their results imply that PKR is involved in the molecular pathways, stimulated by TNF-a and C2-ceramide, that are implicated in the progression of arthritis, since the simulation of arthritis was prevented by inhibiting PKR.

Arthritis is a common problem worldwide. Both osteoarthritis and rheumatoid arthritis cause joint pain and stiffness, which can result in severe pain and disability. Osteoarthritis is the most common form of the disease, affecting more than 2 million Britons and 20 million Americans.

As yet there is no cure for arthritis, and no effective treatments to repair damaged cartilage. The researchers hope that, through understanding more about the molecular pathway in which PKR is involved, they will be able to discover new drug targets for the treatment of arthritis.

###

This release is based on the following article:

Does protein kinase R mediate TNF-a- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?Sophie J Gilbert, Victor C Duance and Deborah J MasonArthritis Res Ther 2004, 6:R46-R55Published 12 November 2003

Upon publication this article will be available online at http://arthritis-research.com/content/6/1/R46, without barrier to access, as per Arthritis Research & Therapy's open access policy.

Arthritis Research & Therapy (http://www.arthritis-research.com) is published by BioMed Central (http://www.biomedcentral.com), an independent online publishing house committed to providing immediate free access to the peer-reviewed biological and medical research. This commitment is based on the view that open access to research is essential to the rapid and efficient communication of science. In addition to open-access original research, BioMed Central also publishes reviews and other subscription-based content.


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Researchers Pinpoint Enzyme Involved In Arthritis Onset." ScienceDaily. ScienceDaily, 13 November 2003. <www.sciencedaily.com/releases/2003/11/031113065353.htm>.
BioMed Central. (2003, November 13). Researchers Pinpoint Enzyme Involved In Arthritis Onset. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2003/11/031113065353.htm
BioMed Central. "Researchers Pinpoint Enzyme Involved In Arthritis Onset." ScienceDaily. www.sciencedaily.com/releases/2003/11/031113065353.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins