Featured Research

from universities, journals, and other organizations

Understanding The Autoimmune Response In Type 1 Diabetes

Date:
February 6, 2004
Source:
Journal Of Clinical Investigation
Summary:
In the February 2 issue of the Journal of Clinical Investigation Mark Peakman and colleagues from King's College London suggest a mechanism for the specificity of the immune regulation that explains why the same peptides present on pancreatic b cells that activate T cells in patients with T1DM and normal individuals cause an autoimmune response in diabetic patients, but no such response in normal individuals.

Type 1 diabetes mellitus (T1DM) is the result of immune-mediated destruction of insulin-secreting pancreatic beta cells. For more than 25 years researchers have searched for an environmental agent or event that triggers this autoimmune response. Past research has suggested that T cells that react to islet beta cells can contribute to the autoimmune response in diabetic patients and also play a part in self-tolerance in healthy individuals. The rarity of these cells and inadequate technology has impaired the examination of this paradigm. In the February 2 issue of the Journal of Clinical Investigation Mark Peakman and colleagues from King's College London suggest a mechanism for the specificity of this immune regulation that explains why the same peptides present on pancreatic b cells that activate T cells in patients with T1DM and normal individuals cause an autoimmune response in diabetic patients, but no such response in normal individuals.

The authors developed a novel assay to examine T cell responses to a panel of epitopes naturally expressed by islet cells and demonstrated that it is the pathways of T cell differentiation and maturation in reaction to these epitopes in T1DM patients (in whom autoimmunity develops) and normal individuals (in whom autoimmunity is arrested) that are different. Upon exposure to antigen, naοve T cells in normal individuals differentiate into T cells that produce IL-10, and possibly TGF- beta, subsequently inhibiting cells that would normally mediate an aggressive immune response. The results reported by Peakman and colleagues suggest that in patients with T1DM, there is instead induction of a predominant number of T cells that produce IFN-gamma and IL-2, which drives an autoaggressive immune response. Why these T cell activation pathways differ between normal and T1DM patients will require further characterization.

In an accompanying commentary, Kevan Herald from the Naomi Berrie Diabetes Center at Columbia University, New York, comments that "these new findings concerning the responses of normal individuals and patients with T1DM to autoantigens shed light on the differences in immune responses between these two groups and the mechanisms of pathogenesis of the disease. The findings suggest ways in which regulation of the autoimmune response occur and offer approaches to immune modulation and ultimately tolerance, the immunologist's "Holy Grail."


Story Source:

The above story is based on materials provided by Journal Of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of Clinical Investigation. "Understanding The Autoimmune Response In Type 1 Diabetes." ScienceDaily. ScienceDaily, 6 February 2004. <www.sciencedaily.com/releases/2004/02/040203232318.htm>.
Journal Of Clinical Investigation. (2004, February 6). Understanding The Autoimmune Response In Type 1 Diabetes. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2004/02/040203232318.htm
Journal Of Clinical Investigation. "Understanding The Autoimmune Response In Type 1 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2004/02/040203232318.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) — Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) — According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins