Featured Research

from universities, journals, and other organizations

Study Links Pulmonary Fibrosis And Heart Disease

Date:
March 10, 2004
Source:
University Of California Los Angeles
Summary:
A new study from UCLA and the University of Pennsylvania shows that patients with pulmonary fibrosis, a progressive lung disease, are more likely also to develop heart disease.

A new study from UCLA and the University of Pennsylvania shows that patients with pulmonary fibrosis, a progressive lung disease, are more likely also to develop heart disease. The study may lead to a greater understanding of both diseases and the role of inflammation, as well as help develop new treatments.

Published in the March 8 issue of the Archives of Internal Medicine, the study showed that patients with pulmonary fibrosis were four times more likely to have extensive coronary artery disease compared with patients without this type of lung condition.

“We were very surprised by the large number of pulmonary fibrosis patients who had also developed advanced coronary artery disease,” said Dr. David A. Zisman, senior author and director of the Interstitial Lung Disease Program and assistant professor of the Division of Pulmonary and Critical Care Medicine at the David Geffen School of Medicine at UCLA.

This is the first study of its kind, and researchers note that pulmonary fibrosis and coronary artery disease may prove very similar — both cause inflammation that leads to scarring and/or plaque development. “Visually the disease processes look very much the same,” Zisman said.

According to Zisman, this study adds to the growing body of research taking a closer look at the impact of the inflammation process throughout the body. “Inflammation plays a key role in so many diseases, from Alzheimer’s disease and heart disease to cancers as well as pulmonary fibrosis,” Zisman said. “The more we learn about the interaction of such diseases, the better we will be able to direct treatments.”

“In the next step of research, we will look more closely at the processes that underlie development of these two diseases,” said Dr. Robert M. Strieter, a study author, chief of the Division of Pulmonary and Critical Care Medicine, and vice chair of medicine at the David Geffen School of Medicine at UCLA. He adds that the disease process generating pulmonary fibrosis in the lungs may have more systemic effects — causing similar inflammation processes in other areas of the body, such as development of coronary artery disease.

According to Strieter, researchers will next try to identify which substances a pulmonary fibrosis lung makes that may reach the heart to produce or exacerbate heart disease.

Study investigators reviewed coronary angiograms of 630 patients at the University of Pennsylvania, who were being evaluated for lung transplant. Although patients had a wide range of lung disorders, those with pulmonary fibrosis had twice the risk of having coronary artery disease and four times the risk of having more extensive coronary artery disease than patients without this condition.

The most common form of pulmonary fibrosis is idiopathic pulmonary fibrosis that affects 5 million worldwide and 100,000 in the United States. The progressive disease causes inflammation and scarring of the lungs and most patients are eventually referred for lung transplant.

Heart disease or coronary artery disease — the No. 1 killer in the United States — causes blockages of the arteries that feed the heart muscle, which could lead to a heart attack.

The study was funded by the National Institutes of Health and a private donation.

Additional study authors include Dr. Jorge R. Kizer, Division of Cardiology, Departments of Medicine and Public Health, Weill Medical College of Cornell University, New York City; Nancy P. Blumenthal, Dr. Robert M. Kotloff and Dr. John Hansen-Flaschen, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia; Dr. Stephen E. Kimmel; Dr. Victor A. Ferrari, Cardiovascular Division of the Department of Medicine and the Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia; and Dr. Selim M. Arcasoy, Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Columbia University College of Physicians and Surgeons, New York City.


Story Source:

The above story is based on materials provided by University Of California Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University Of California Los Angeles. "Study Links Pulmonary Fibrosis And Heart Disease." ScienceDaily. ScienceDaily, 10 March 2004. <www.sciencedaily.com/releases/2004/03/040310080526.htm>.
University Of California Los Angeles. (2004, March 10). Study Links Pulmonary Fibrosis And Heart Disease. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2004/03/040310080526.htm
University Of California Los Angeles. "Study Links Pulmonary Fibrosis And Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2004/03/040310080526.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins