Featured Research

from universities, journals, and other organizations

Embryonic Stem Cells Induced To Develop Into Bone Marrow And Blood Cells

Date:
April 1, 2004
Source:
Northwestern University
Summary:
Researchers at Northwestern University have devised a method to induce embryonic stem cells to develop into bone marrow and blood cells. Injecting the stem cells into the bone marrow cavity of mice whose bone marrow cells had been depleted restored production of blood cells, including cells of the immune system, which normally are created in the bone marrow.

Researchers at Northwestern University have devised a method to induce embryonic stem cells to develop into bone marrow and blood cells. Injecting the stem cells into the bone marrow cavity of mice whose bone marrow cells had been depleted restored production of blood cells, including cells of the immune system, which normally are created in the bone marrow.

As reported by Richard K. Burt, M.D., and colleagues in April issue of The Journal of Experimental Medicine, the method was effective even in genetically mismatched mice. If the same results can be produced in humans, the technique may eventually eliminate the need to find genetically matched human bone marrow donors for persons with leukemia, autoimmune diseases and other immune disorders, Burt said.

Burt is associate professor of medicine and chief of immunotherapy for autoimmune diseases at the Feinberg School of Medicine at Northwestern University.

Embryonic stem cells, which are derived from embryos, have the potential to grow into many different cell types. Burt and colleagues identified the most effective mix of growth factors to induce stem cells in culture to develop into precursor bone marrow and blood cells. They also developed a technique to select the most viable cells for injection.

Despite the genetic mismatch between donor and recipient mice, the injected cells were not rejected. The injected cells matured into a new immune system that recognized the recipient as self.

Blood or marrow stem cells from a sibling or an unrelated or cord blood registry often fail to develop tolerance to the recipient or patient into which they are infused – an often-fatal complication after bone marrow transplantation that is known as graft-versus-host disease.

But in the study, after embryonic stem cell transplantation the mice's immune response, while tolerant to self, responded to foreign substances normally, indicating that recipients are able to fight off infection. Although the use of human embryonic stem cell lines is controversial, it has many advantages over the use of donor bone marrow or blood cells, which are highly variable, cannot be cultured in a laboratory, may cause lethal graft-versus-host disease and are often not available to patients due to inability to find a suitably matched donor.

Human embryonic stem cell lines can be cultured indefinitely, providing a permanently renewable alternative marrow source that restores blood cell production with an intact immune response without causing graft-versus-host disease.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "Embryonic Stem Cells Induced To Develop Into Bone Marrow And Blood Cells." ScienceDaily. ScienceDaily, 1 April 2004. <www.sciencedaily.com/releases/2004/04/040401081637.htm>.
Northwestern University. (2004, April 1). Embryonic Stem Cells Induced To Develop Into Bone Marrow And Blood Cells. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2004/04/040401081637.htm
Northwestern University. "Embryonic Stem Cells Induced To Develop Into Bone Marrow And Blood Cells." ScienceDaily. www.sciencedaily.com/releases/2004/04/040401081637.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins