Featured Research

from universities, journals, and other organizations

Grow Your Own Teeth

Date:
May 4, 2004
Source:
National Endowment For Science, Technology And The Arts
Summary:
People who have lost or damaged teeth could soon be growing their own, thanks to a major scientific breakthrough by a start-up, Odontis Ltd, formed by King’s College, London.

People who have lost or damaged teeth could soon be growing their own, thanks to a major scientific breakthrough by a start-up, Odontis Ltd, formed by King’s College, London. An investment of 400,000 from NESTA (the National Endowment for Science, Technology and the Arts) – the organisation that nurtures UK creativity and innovation and the Wellcome Trust biomedial research charity, will enable the company to move onto the next stage of development.

Related Articles


Damaged or missing teeth are a large and significant problem with dentures, bridges or synthetic implants being the only treatment currently available. These methods are often invasive and surgically traumatic.

Odontis’ pioneering technology will allow the patient to grow his or her own natural replacement teeth instead of having a synthetic implant. As well as the benefit of not experiencing surgical trauma, there is also the psychological boost of ‘having one’s own teeth’.

The project is the brainchild of genetic research scientist, Professor Paul Sharpe, who is currently the Head of Division of Craniofacial Biology and Biomaterials of the Dental Institute, Kings College London. His discovery is based on human stem cell technology.

Stem cells are taken from the patient, treated and cultured in a laboratory, then re-implanted in the patient’s jaw under the gum at the site of the missing or extracted tooth. This then grows into a fully-formed, live tooth in the same way that teeth develop naturally.

To date, no companies or research groups in the world have been able to demonstrate the formation of a living, natural tooth.

In both the US and UK, adults aged over 50 lose on average 12 teeth, including four wisdom molars, from a full complement of 32 teeth. Lost teeth can lead to problems with health, nutrition and appearance.

On receiving NESTA’s investment, Professor Sharpe says: “We are delighted to receive this investment from NESTA and the Wellcome Trust. It will be a major help in taking the technology forward which will be eventually used on patients.”

The project is receiving a total investment of 500,000: 100,000 from NESTA, 300,000 University Translation Award from the Wellcome Trust and 100,000 from a business angel. Kinetique Biomedical Seed Fund has already invested 250,000 in the proof of concept phase.

Professor Sharpe, adds: “A key medical advantage of our technology is that a living tooth can preserve the health of the surrounding tissues much better than artificial prosthesis. Teeth are living, and they are able to respond to a person’s bite. They move, and in doing so they maintain the health of the surrounding gums and teeth.”

Mark White, NESTA Invention and Innovation Director, says: “Odontis have come up with a dental method that is highly innovative and pioneering in its approach. We hope that our seed investment will bring about a major success story for UK the research and science community.”

Notes to editors

In the US more than 20 million people are missing their natural teeth, with more than 100 million people missing 11-15 teeth.

In 2001 there were 252,000 implant procedures.

The global dental implant market is forecast to grow at around 15-20% per annum for the next 5-6 years, meaning that the market would rise from US$900 million at present to around US$1.5 billion by 2007.

The Wellcome Trust is an independent research-funding charity established in 1936 under the will of Sir Henry Wellcome. The Trust's mission is to promote research with the aim of improving human and animal health and it currently spends around 400m p.a. The Technology Transfer Division manages the charity's intellectual property portfolio and related matters and also provides translation funding for early-stage healthcare technology development. Over 70 research and license agreements have been transacted and the Division has an interest in around 30 early-stage life science companies in the UK and US.

King’s is one of the oldest and largest colleges of the University of London with 13,800 undergraduate students and some 5,300 postgraduates in ten schools of study. The Dental Institute was awarded the maximum research (5*) and teaching (24) rating in national exercises.

• NESTA (the National Endowment for Science, Technology and the Arts) was established by Act of Parliament in 1998 to pioneer ways of supporting and promoting talent, innovation and creativity in science, technology and the arts.

• NESTA’s income initially came from the interest on an endowment of 200 million from National Lottery funds. In February 2003, NESTA received an additional 50 million bringing the endowment up to 250 million and an extra 45 million to use as revenue expenditure until 2006 (15 million a year from 2003). NESTA plans to spend over 20 million a year on UK creativity and innovation.

• Since May 2000, NESTA has spent over 40 million on more than 387 awards.

• NESTA has a dedicated Media Room on its web site where news releases like this are easily available and where journalists can subscribe to receive any future releases. Other information, including high-resolution images to download and Press Office contact details, are also available at http://www.nesta.org.uk/mediaroom


Story Source:

The above story is based on materials provided by National Endowment For Science, Technology And The Arts. Note: Materials may be edited for content and length.


Cite This Page:

National Endowment For Science, Technology And The Arts. "Grow Your Own Teeth." ScienceDaily. ScienceDaily, 4 May 2004. <www.sciencedaily.com/releases/2004/05/040504063535.htm>.
National Endowment For Science, Technology And The Arts. (2004, May 4). Grow Your Own Teeth. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2004/05/040504063535.htm
National Endowment For Science, Technology And The Arts. "Grow Your Own Teeth." ScienceDaily. www.sciencedaily.com/releases/2004/05/040504063535.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins