Featured Research

from universities, journals, and other organizations

Cutting Tumor Supply Lines May Boost Cancer Treatments, UF Professor Says

Date:
May 13, 2004
Source:
University Of Florida
Summary:
Scientists have long viewed the network of blood vessels tumors create to siphon oxygen and other nutrients from the body as a potential target for therapies geared toward stopping tumors in their tracks. But efforts to block blood vessel development or impede existing vessels in tumors in the lab haven't met with as much success as some had hoped.

GAINESVILLE, Fla. --- Scientists have long viewed the network of blood vessels tumors create to siphon oxygen and other nutrients from the body as a potential target for therapies geared toward stopping tumors in their tracks. But efforts to block blood vessel development or impede existing vessels in tumors in the lab haven’t met with as much success as some had hoped.

Now Dr. Dietmar W. Siemann, a University of Florida researcher who reviewed findings from published studies that tested a class of drugs known as vascular disrupting agents - designed to disrupt blood flow to tumors - says using them in combination with chemotherapy, radiation or heat appears to be more effective than using them alone.

“Agents designed to directly attack tumor blood vessels provide a new approach to significantly improve the effectiveness of radiotherapy and chemotherapy in cancer treatment,” said Siemann, a professor in the department of radiation oncology at the UF Shands Cancer Center.

Siemann will publish a paper describing the results of his review, which sought to determine the effectiveness of these drugs to date on the basis of findings from preclinical studies, in the May 10 online edition of CANCER, the journal of the American Cancer Society.

He collaborated with researchers from Aarhus University in Denmark and Boston’s Oxigene Inc., which manufacturers one such drug.

The authors found that vascular disrupting agents interfered with existing blood vessels and cut tumor blood flow in animals and human tumors studied in a laboratory setting. Most of the tumor tissue died, but the drugs - which home in on immature blood vessels the tumor forms but spare normal vessels - were not able to destroy all tumor cells. Using chemotherapy, radiation or heat in combination with the drugs, however, led to better results, Siemann said.

The concept of using drugs to interfere with and halt new blood vessel growth was pioneered in animal research by Dr. Judah Folkman, a cancer researcher at Harvard University. The late Juliana Denekamp, of Umea University, Sweden, is credited with developing the idea to use vascular targeting agents to directly damage blood vessels and thereby kill tumor cells by starving them of nutrients. Their findings, which gained national attention in 1998, inspired thousands of follow-up studies.

At a national medical conference last year, Siemann reported he and other UF scientists significantly delayed the growth of cancerous human tumors in mice by combining a drug that thwarts blood vessel formation with a vascular disrupting agent that destroys existing vessels. Siemann added that more extensive research is needed to determine whether the beneficial effects observed in mice and in tissues studied in the laboratory can be duplicated in human cancer patients. He and his research team recently received a $1.2 million, four-year grant renewal from the National Cancer Institute to continue his studies.


Story Source:

The above story is based on materials provided by University Of Florida. Note: Materials may be edited for content and length.


Cite This Page:

University Of Florida. "Cutting Tumor Supply Lines May Boost Cancer Treatments, UF Professor Says." ScienceDaily. ScienceDaily, 13 May 2004. <www.sciencedaily.com/releases/2004/05/040512043138.htm>.
University Of Florida. (2004, May 13). Cutting Tumor Supply Lines May Boost Cancer Treatments, UF Professor Says. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2004/05/040512043138.htm
University Of Florida. "Cutting Tumor Supply Lines May Boost Cancer Treatments, UF Professor Says." ScienceDaily. www.sciencedaily.com/releases/2004/05/040512043138.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins