May 25, 2004 UK researchers writing in Europe's leading reproductive medicine journal Human Reproduction, report (Tuesday 25 May) what they believe to be a world record – a baby born using sperm that had been frozen for 21 years.
"We believe this is the longest period of sperm cryopreservation resulting in a live birth so far reported in the scientific literature," according to one of the authors, Dr Elizabeth Pease, Consultant in Reproductive Medicine at the Department of Reproductive Medicine at St Mary's Hospital, Manchester.
A healthy baby boy was born two years ago to a couple after the father had been successfully treated for testicular cancer with surgery, radiotherapy and chemotherapy between 1979 and 1981.
Following diagnosis at the age of 17 but before treatment, which was to leave him sterile, five ampoules of sperm were frozen. Long term storage continued until he married and wished to have a family. ICSI – the technique that involves a single sperm being injected into an egg – was used to fertilise his partner's eggs. The baby was born after the fourth IVF cycle, when two of the embryos that had been frozen at the start of IVF treatment were transferred to his partner's uterus.
"Even after 21 years of storage, the percentage of motile sperm after thawing was high," said Greg Horne, Senior Embryologist. "This case report provides evidence that long-term freezing can successfully preserve sperm quality and fertility. This is important to know because semen stored by young cancer patients is undertaken at a time of great emotional stress when future fertility is unlikely to be an immediate priority.
"It also suggests that we need to extend follow-up studies of cryobanked sperm up to 25 years at least. A recent study showed that only 27% of men who stored semen at our centre prior to cancer treatment used their samples within 10 years, and in the UK regulations allow sperm to be stored until a man is 55."
The couple, speaking anonymously, were keen that their case be reported as an example of the safety and success of long-term sperm freezing and to help encourage young cancer patients to think positively about the future at a time when they are under considerable emotional stress because of their diagnosis and impending treatment. They were also anxious to point out that had it not been for sperm banking and IVF treatment being available on the NHS they would not have had the opportunity to become parents.
 Case report: live birth with sperm cryopreserved for 21 years prior to cancer treatment. Human Reproduction. Vol 19. No 6 pp 1448-1449.
Notes: 1 PDF version of this press release and full embargoed text of the paper with complete results can be found from 09:00hrs London time Monday 24 May at: http://www3.oup.co.uk/eshre/press-release/jun04.pdf or is available from Margaret Willson.
2 Human Reproduction is a monthly journal of the European Society of Human Reproduction and Embryology (ESHRE). Please acknowledge Human Reproduction as a source. Dr Helen Beard, Managing Editor. Tel: 44-195-421-2404 Email: email@example.com
3 ESHRE's website is: http://www.eshre.com
4 Abstracts of other papers in ESHRE's three journals: Human Reproduction, Molecular Human Reproduction & Human Reproduction Update can be accessed post embargo from http://www3.oup.co.uk/eshre/ Full text of papers available on request from Margaret Willson.
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