Featured Research

from universities, journals, and other organizations

Imaging Technology May Be Used To Diagnose Melancholic Depression

Date:
July 7, 2004
Source:
Yale University
Summary:
In the brain, low levels of the inhibitory transmitter GABA and high levels of the excitatory neurotransmitter glutamate appear to be strongly associated with a particular type of depression, according to a study by Yale researchers.

In the brain, low levels of the inhibitory transmitter GABA and high levels of the excitatory neurotransmitter glutamate appear to be strongly associated with a particular type of depression, according to a study by Yale researchers.

The findings were made using proton magnetic resonance spectroscopy to observe the levels of GABA and glutamate in 38 healthy persons and 33 subjects with major depressive disorder. The study is published in the Archives of General Psychiatry.

Author Gerard Sanacora, assistant professor of psychiatry at Yale School of Medicine and director of the Yale Depression Research Program, said the reductions in cortical GABA and increased glutamate were particularly associated with the presence of melancholic and psychotic features in patients with major depressive disorder. Melancholia is a relatively common form of depression marked by insomnia, loss of appetite, and loss of pleasure.

"Depressed subjects with melancholic features appear to have the largest and most consistent GABA reductions," Sanacora said. "This appears to be especially clear in the subset of melancholic subjects who also have psychotic features. In contrast, normal or near normal GABA concentrations were found in the majority of atypically depressed subjects."

Sanacora said the findings add to mounting evidence suggesting that in addition to the monoaminergic systems (serotonin and norepinepherine), both the GABA and glutamate systems also contribute to the pathophysiology and treatment of mood disorders. By demonstrating that the abnormalities are limited to a subset of depressed subjects, these results may ultimately help doctors make more accurate diagnoses that could more effectively guide treatment planning.

"At the moment, we have limited ability to predict how a patient will respond to one treatment for depression compared to another," he said. "We are very interested in exploring the usefulness of these and other biological markers in identifying various subtypes of depression and predicting specific treatment responses." The work was supported by The Patrick and Catherine Weldon Donaghue Medical Research Foundation, the National Alliance for Research in Schizophrenia and Depression, and the National Institute of Mental Health.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Imaging Technology May Be Used To Diagnose Melancholic Depression." ScienceDaily. ScienceDaily, 7 July 2004. <www.sciencedaily.com/releases/2004/07/040706082633.htm>.
Yale University. (2004, July 7). Imaging Technology May Be Used To Diagnose Melancholic Depression. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2004/07/040706082633.htm
Yale University. "Imaging Technology May Be Used To Diagnose Melancholic Depression." ScienceDaily. www.sciencedaily.com/releases/2004/07/040706082633.htm (accessed April 24, 2014).

Share This



More Mind & Brain News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
Do We Get Nicer With Age?

Do We Get Nicer With Age?

Newsy (Apr. 22, 2014) A recent report claims personality can change over time as we age, and usually that means becoming nicer and more emotionally stable. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins