Featured Research

from universities, journals, and other organizations

Heart Failure Patients Respond Well To Beta-blocker Drugs

Date:
July 14, 2004
Source:
Yale University
Summary:
Heart failure patients who undergo beta-blocker therapy tolerated the treatment well and had less heart failure deterioration than placebo drugs, researchers at Yale School of Medicine and other institutions report in the July 12 issue of Archives of Internal Medicine.

Heart failure patients who undergo beta-blocker therapy tolerated the treatment well and had less heart failure deterioration than placebo drugs, researchers at Yale School of Medicine and other institutions report in the July 12 issue of Archives of Internal Medicine.

"Beta-blocker drugs not only save the lives of patients with chronic heart failure, but patients are less likely to stop taking these medications than the placebo, indicating how well-tolerated they are," said senior author Harlan M. Krumholz, M.D., professor of internal medicine and cardiology at Yale School of Medicine. "This study is meant to address the concerns on the part of the medical community, that beta-blockers may cause adverse effects in this population."

Beta-blockers are any of a group of drugs widely used in the treatment of patients with heart disease and hypertension. The drugs decrease the rate and force of heart contraction by blocking the beta-adrenergic receptors of the autonomic nervous system.

Krumholz and colleagues reviewed data from nine randomized trials comparing beta-blockers with placebo in heart failure patients in order to measure the risks of adverse effects. They found a 27 percent relative reduction in mortality. They also found that adverse effects of beta-blockers were low compared to control, which they said should alleviate concerns about beta-blocker risk factors.

Concerns among physicians that beta-blockers are associated with side effects, may have kept some from prescribing the therapy, but Krumholz said this should not deter physicians from using this effective class of medications.

"While it is true that beta-blocker therapy is associated with some side-effects, such as hypotension -- low blood pressure, dizziness and slow heart beat, the increases in risks are small, and fewer patients stopped taking beta-blocker therapy due to side effects than from placebo," said Krumholz, who is also an attending cardiologist and director of the CORE Program at Yale-New Haven Hospital.

Other authors on the study included first author Dennis T. Ko, M.D., of the University of Toronto; Patricia R. Hebert, Jeptha P. Curtis, M.D., and JoAnne M. Foody, M.D., of Yale School of Medicine; Christopher S. Coffey of the University of Alabama at Birmingham; and Artyom Sedrakyan, M.D., of the Royal College of Surgeons, London, England.

###

Citation: Archives of Internal Medicine, Vol. 164, July 12, 2004.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Heart Failure Patients Respond Well To Beta-blocker Drugs." ScienceDaily. ScienceDaily, 14 July 2004. <www.sciencedaily.com/releases/2004/07/040714090435.htm>.
Yale University. (2004, July 14). Heart Failure Patients Respond Well To Beta-blocker Drugs. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2004/07/040714090435.htm
Yale University. "Heart Failure Patients Respond Well To Beta-blocker Drugs." ScienceDaily. www.sciencedaily.com/releases/2004/07/040714090435.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins