Featured Research

from universities, journals, and other organizations

New Database To Help Develop AIDS Drugs

Date:
July 16, 2004
Source:
National Institute Of Standards And Technology
Summary:
Researchers who are either developing drug treatments for AIDS or studying the virus that causes the disease have a new resource—an online database of AIDS-related protein structures just unveiled for public use by the National Institute of Standards and Technology (NIST).

When an inhibitor drug (small multicolored molecule in center) binds to the active site of the HIV protease (space right below the small round, yellow and red fragments), the enzyme does not function and the HIV virus cannot grow.
Credit: Image courtesy of National Institute of Standards and Technology

Researchers who are either developing drug treatments for AIDS or studying the virus that causes the disease have a new resource—an online database of AIDS-related protein structures just unveiled for public use by the National Institute of Standards and Technology (NIST).

Developed in collaboration with the National Cancer Institute, the HIV Structural Reference Database (http://xpdb.nist.gov/hivsdb/hivsdb.html) will receive, annotate, archive and distribute structural data for proteins involved in making HIV, the virus that causes AIDS, as well as molecules that inhibit these activities. Until now, much of this information was not widely available because it was unpublished. The new database contains data from both the published literature and from direct contributions by industrial and other laboratories.

The database will be especially useful in developing strategies for inhibiting the activities of the HIV protease (see image) that is essential for maturation of HIV. In addition, the database is expected to help scientists understand and circumvent the problem of mutations that make HIV resistant to certain drugs.

NIST scientists annotate the structural data with information from various sources and index—or classify—the entries so that users can reliably find particular structures. They helped to develop a novel technique for indexing HIV protease inhibitors, enabling scientists to rapidly and reliably get data on all enzyme-inhibitor complexes such as a mutant strain that is resistant to a particular drug.

NIST has a long history of producing, evaluating and disseminating chemical data and is increasingly applying this expertise in biosciences. The HIV database is a model for developing and testing new technology to annotate and standardize HIV inhibitor names, and for evaluating structural data for macromolecules.


Story Source:

The above story is based on materials provided by National Institute Of Standards And Technology. Note: Materials may be edited for content and length.


Cite This Page:

National Institute Of Standards And Technology. "New Database To Help Develop AIDS Drugs." ScienceDaily. ScienceDaily, 16 July 2004. <www.sciencedaily.com/releases/2004/07/040716080813.htm>.
National Institute Of Standards And Technology. (2004, July 16). New Database To Help Develop AIDS Drugs. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2004/07/040716080813.htm
National Institute Of Standards And Technology. "New Database To Help Develop AIDS Drugs." ScienceDaily. www.sciencedaily.com/releases/2004/07/040716080813.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins