Featured Research

from universities, journals, and other organizations

Topical Medication Effective In Relieving Symptoms Of Knee Osteoarthritis

Date:
October 15, 2004
Source:
Journal Of The American Medical Association
Summary:
Symptoms of primary osteoarthritis of the knee, including pain and stiffness, were significantly improved in patients who used a topical nonsteroidal anti-inflammatory drug (NSAID), according to an article in the October 11 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.

CHICAGO -- Symptoms of primary osteoarthritis of the knee, including pain and stiffness, were significantly improved in patients who used a topical nonsteroidal anti-inflammatory drug (NSAID), according to an article in the October 11 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.

According to the article, nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for treating symptoms of osteoarthritis (OA), a joint disease affecting an increasingly large percentage of the aging population. However, oral NSAIDs carry the common risk of adverse effects on the gastrointestinal (GI) tract, the liver, and the kidneys. Topical NSAIDs may offer an alternative oral medication with a reduction in adverse effects, especially on the GI tract, the article states.

Sanford H. Roth, M.D., of Arizona Research & Education, Phoenix, and colleagues tested the efficacy of a topical diclofenac sodium solution (an NSAID) in the treatment of knee OA. The trial was conducted from December 2000 to May 2001 and studied 228 men and women aged 40 to 85 years with primary OA in at least one knee. Patients were randomized to receive 40 drops of the diclofenac solution applied to the affected knees or a control solution four times daily during the 12-week study.

The researchers found that the topical diclofenac solution was significantly more effective than the control solution in improving symptoms of knee osteoarthritis. Patients who applied the diclofenac solution experienced a 45.7 percent reduction in their ratings of knee pain. Scores on scales rating physical function and stiffness also improved by 36.7 percent and 35.1 percent, respectively. Patients in the diclofenac group also experienced a 45 percent improvement in the score for pain with walking.

Most adverse effects related to using the diclofenac were skin reactions at the site of application. Sixty-eight people (41.5 percent) using the diclofenac solution experienced minor skin irritation. In both the diclofenac and control groups, dry skin and rash were most frequent, occurring in 60 of 164 of those using diclofenac, and 18 of 164 of people using the control solution.

The authors write: "This study demonstrates that topical diclofenac solution ...effectively treats symptoms of primary OA of the knee. Superior efficacy compared with the vehicle-control solution was demonstrated for all defined efficacy variables-[scaled] pain, physical function, and stiffness subscales; pain on walking, and a patient global assessment."

###

(Arch Intern Med. 2004;164:2017-2023. Available post-embargo at archinternmed.com)

Editor's Note: This study was supported by Dimethaid Health Care Ltd., Markham, Ontario. Dr. Shainhouse owns stock in Dimethaid Health Care Ltd.


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "Topical Medication Effective In Relieving Symptoms Of Knee Osteoarthritis." ScienceDaily. ScienceDaily, 15 October 2004. <www.sciencedaily.com/releases/2004/10/041012085525.htm>.
Journal Of The American Medical Association. (2004, October 15). Topical Medication Effective In Relieving Symptoms Of Knee Osteoarthritis. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2004/10/041012085525.htm
Journal Of The American Medical Association. "Topical Medication Effective In Relieving Symptoms Of Knee Osteoarthritis." ScienceDaily. www.sciencedaily.com/releases/2004/10/041012085525.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins