Featured Research

from universities, journals, and other organizations

The Anti-arthritic Effects Of Bee Venom: Study Reveals How Melittin In Venom Blocks Inflammation

Date:
November 9, 2004
Source:
John Wiley & Sons, Inc.
Summary:
Since ancient times, healers have practiced apitherapy, the use of honeybee products for curative purposes. Within the last few decades, conventional doctors have joined holistic practitioners in exploring the potential of bee venom for treating a wide variety of conditions from acute tendonitis to chronic back pain to rheumatoid arthritis (RA).

Since ancient times, healers have practiced apitherapy, the use of honeybee products for curative purposes. Within the last few decades, conventional doctors have joined holistic practitioners in exploring the potential of bee venom for treating a wide variety of conditions from acute tendonitis to chronic back pain to rheumatoid arthritis (RA). While research has established anti-arthritic effects of bee venom, much about the way bee venom work remains a mystery.

A team of researchers in South Korea recently conducted an investigation into the molecular mechanisms behind bee venom's therapeutic impact on RA, a chronic, destructive inflammatory disease. The November 2004 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis) presents their insights into melittin, a major component of bee venom and a powerful anti-inflammatory agent.

To gain a better understanding of bee venom's potential benefits for RA patients, the researchers examined its action in rat treated to induce inflammatory arthritis. For rats with advanced RA, treatment with bee venom at very low doses resulted in dramatic reductions of tissue swelling and osteophyte formation on affected paws. "Although the issue for determination of an effective dose is needed for further study," observes one of the authors, Jin Tae Hong, M.D., Ph.D. "Our data show that the anti-arthritic effects of bee venom are related to the anti-inflammatory effects of bee venom."

In the next phase of their study, researchers examined the anti-inflammatory effects of bee venom on synovial cells – cells lining the joints– obtained from human RA patients. Their experiments focused on melittin, bee venom's principal peptide. They observed melittin's power to block the expression of inflammatory genes, much like COX-2 inhibitor drugs used to treat RA. Melittin effectively reduces inflammation by inhibiting the critical DNA binding activity of NF-kB (Nuclear Factor kappa B), which directly controls a number of genes involved in immune reactions. Thus, Melittin's targeted inactivation of inflammation may hold the key to the anti-arthritic effects of bee venom.

"The potency of melittin in the inhibition of the inflammatory response may be of great benefit in degenerative and inflammatory diseases such as RA," concludes Dr. Hong. "The extent of inhibitory effects of melittin in most parameters determined in the present study is similar to or greater than bee venom itself, suggesting that melittin may be a major causative component in the pharmacologic effects of bee venom."

###

Article: "Antiarthritic Effect of Bee Venom: Inhibition of Inflammation Mediator Generation by Suppression of NF-ęB Through Interaction With the p50 Subunit," Hye Ji Park, Seong Ho Lee, Dong Ju Son, Ki Wan Oh, Ki Hyun Kim, Ho Seub Song, Goon Joung Kim, Goo Taeg Oh, Do Young Yoon, and Jin Tae Hong, Arthritis & Rheumatism, November 2004; 50:11; pp. 3504-3515 (DOI: 10.1002/art.20626).


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "The Anti-arthritic Effects Of Bee Venom: Study Reveals How Melittin In Venom Blocks Inflammation." ScienceDaily. ScienceDaily, 9 November 2004. <www.sciencedaily.com/releases/2004/11/041108030833.htm>.
John Wiley & Sons, Inc.. (2004, November 9). The Anti-arthritic Effects Of Bee Venom: Study Reveals How Melittin In Venom Blocks Inflammation. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2004/11/041108030833.htm
John Wiley & Sons, Inc.. "The Anti-arthritic Effects Of Bee Venom: Study Reveals How Melittin In Venom Blocks Inflammation." ScienceDaily. www.sciencedaily.com/releases/2004/11/041108030833.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) — Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) — Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) — Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins