Featured Research

from universities, journals, and other organizations

Breast Conserving Therapy Safe For Hereditary Breast Cancer

Date:
December 2, 2004
Source:
John Wiley & Sons, Inc.
Summary:
Women with hereditary breast cancer treated with breast conserving therapy appear to have no increased risk for recurrence in the treated breast, according to results from a prospective study published in the January 1, 2005 issue of CANCER, a peer-reviewed journal of the American Cancer Society. However, the risk of breast cancer in the opposite breast is significantly increased.

Women with hereditary breast cancer treated with breast conserving therapy appear to have no increased risk for recurrence in the treated breast, according to results from a prospective study published in the January 1, 2005 issue of CANCER, a peer-reviewed journal of the American Cancer Society. However, the risk of breast cancer in the opposite breast is significantly increased.

Related Articles


Breast conserving therapy (BCT), consisting of lumpectomy and radiation, has been demonstrated to be a safe, effective treatment for non-hereditary or sporadic forms of early breast cancer. However, for hereditary breast cancers – i.e., mutations in BRCA1 and BRCA2 genes – the use of BCT is controversial due to conflicting data about increased risk of recurrence in the treated breast and development of new tumors in the untreated breast. This leaves women with BRCA mutations at a disadvantage when choosing between BCT and bilateral mastectomy.

Mark Robson, M.D. and his colleagues from Memorial Sloan-Kettering Cancer Center in New York City followed 87 women diagnosed with breast cancer and BRCA mutations who were treated with BCT to evaluate their long-term cancer risks.

The investigators found no increase in the risk of cancer recurrence in the treated breast, compared to young women without mutations. Ten years after their initial diagnosis, 13.6 percent of the women with a genetic mutation had experienced a recurrence similar to previously published recurrence rates for women with non-hereditary breast cancers treated with BCT. However, the researchers note that more than half the women suffered a cancer-related event (recurrence or second primary cancer) within ten years of their initial diagnosis, including 37.6 percent who experienced a new cancer in the untreated breast. No clinical risk factors were linked to an increased risk of cancer.

"Breast conserving treatment," conclude the authors, "is a reasonable option for [women with BRCA mutations], and the indications for unilateral mastectomy should be the same for both hereditary and non-hereditary breast cancer." They caution, however, "discussion of bilateral mastectomy is warranted by the significant contralateral breast cancer risk."

###

Article: "Appropriateness of Breast-Conserving Treatment of Breast Carcinoma in Women with Germline Mutations in BRCA1 or BRCA2: A Clinic-Based Series," Mark Robson, Tiffany Svahn, Beryl McCormick, Patrick Borgen, Clifford A Hudis, Larry Norton, Kenneth Offit, CANCER; Published Online: November 22, 2004 (DOI: 10.1002/cncr.20728); Print Issue Date: January 1, 2005.


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Breast Conserving Therapy Safe For Hereditary Breast Cancer." ScienceDaily. ScienceDaily, 2 December 2004. <www.sciencedaily.com/releases/2004/11/041123113703.htm>.
John Wiley & Sons, Inc.. (2004, December 2). Breast Conserving Therapy Safe For Hereditary Breast Cancer. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2004/11/041123113703.htm
John Wiley & Sons, Inc.. "Breast Conserving Therapy Safe For Hereditary Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/2004/11/041123113703.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins