Featured Research

from universities, journals, and other organizations

UCLA/VA Research Explains Alzheimer's Link To Diabetes; Shows Protective Effect Of Low-fat Diet

Date:
December 16, 2004
Source:
University Of California - Los Angeles
Summary:
Insulin-degrading enzyme (IDE) is a protein known to play a role in eliminating amyloid peptides that cause destructive plaques and tangles in the brains of Alzheimer's patients. Until now, little has been known about the cellular and molecular regulation of IDE.

Insulin-degrading enzyme (IDE) is a protein known to play a role in eliminating amyloid peptides that cause destructive plaques and tangles in the brains of Alzheimer's patients. Until now, little has been known about the cellular and molecular regulation of IDE.

Related Articles


Using animal models and human tissue, the research team 1) identified a shortfall of IDE protein in the brains of Alzheimer's disease patients; 2) found a cause-effect relationship between insulin signaling and increased production of IDE, and 3) demonstrated that a low-fat diet high in fish and soy can increase production of IDE.

The findings for the first time explain the association between insulin-resistant Type 2 diabetes and Alzheimer's disease, and demonstrate the ability to manipulate levels of the protective IDE protein through diet.

The lead author was Greg M. Cole, professor of medicine and neurology at the David Geffen School of Medicine at UCLA , associate director of the UCLA Alzheimer's Disease Research Center, and associate director of the Geriatric Research and Education and Clinical Center at the VA Greater Los Angeles Healthcare System, Sepulveda.

Citation: The Journal of Neuroscience, Dec. 8, 2004.

###

Funders: National Institutes of Health and the UCLA Alzheimer's Disease Research Center.


Story Source:

The above story is based on materials provided by University Of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Los Angeles. "UCLA/VA Research Explains Alzheimer's Link To Diabetes; Shows Protective Effect Of Low-fat Diet." ScienceDaily. ScienceDaily, 16 December 2004. <www.sciencedaily.com/releases/2004/12/041208084742.htm>.
University Of California - Los Angeles. (2004, December 16). UCLA/VA Research Explains Alzheimer's Link To Diabetes; Shows Protective Effect Of Low-fat Diet. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2004/12/041208084742.htm
University Of California - Los Angeles. "UCLA/VA Research Explains Alzheimer's Link To Diabetes; Shows Protective Effect Of Low-fat Diet." ScienceDaily. www.sciencedaily.com/releases/2004/12/041208084742.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins